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Malignant Peripheral Nerve Sheath Tumors State of the Science: Leveraging Clinical and Biological Insights into Effective Therapies
Joint Authors
Kim, AeRang
Stewart, Douglas R.
Reilly, Karlyne M.
Viskochil, David
Miettinen, Markku M.
Widemann, Brigitte C.
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-16
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Malignant peripheral nerve sheath tumor (MPNST) is the leading cause of mortality in patients with neurofibromatosis type 1.
In 2002, an MPNST consensus statement reviewed the current knowledge and provided guidance for the diagnosis and management of MPNST.
Although the improvement in clinical outcome has not changed, substantial progress has been made in understanding the natural history and biology of MPNST through imaging and genomic advances since 2002.
Genetically engineered mouse models that develop MPNST spontaneously have greatly facilitated preclinical evaluation of novel drugs for translation into clinical trials led by consortia efforts.
Continued work in identifying alterations that contribute to the transformation, progression, and metastasis of MPNST coupled with longitudinal follow-up, biobanking, and data sharing is needed to develop prognostic biomarkers and effective prevention and therapeutic strategies for MPNST.
American Psychological Association (APA)
Kim, AeRang& Stewart, Douglas R.& Reilly, Karlyne M.& Viskochil, David& Miettinen, Markku M.& Widemann, Brigitte C.. 2017. Malignant Peripheral Nerve Sheath Tumors State of the Science: Leveraging Clinical and Biological Insights into Effective Therapies. Complexity،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1197742
Modern Language Association (MLA)
Kim, AeRang…[et al.]. Malignant Peripheral Nerve Sheath Tumors State of the Science: Leveraging Clinical and Biological Insights into Effective Therapies. Complexity No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1197742
American Medical Association (AMA)
Kim, AeRang& Stewart, Douglas R.& Reilly, Karlyne M.& Viskochil, David& Miettinen, Markku M.& Widemann, Brigitte C.. Malignant Peripheral Nerve Sheath Tumors State of the Science: Leveraging Clinical and Biological Insights into Effective Therapies. Complexity. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1197742
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1197742