Abnormal N400 Semantic Priming Effect May Reflect Psychopathological Processes in Schizophrenia: A Twin Study
Joint Authors
Weisbrod, Matthias
Sharma, Anuradha
Sauer, Heinrich
Hill, Holger
Kaufmann, Claudia
Bender, Stephan
Source
Schizophrenia Research and Treatment
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-28
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Objective.
Activation of semantic networks is indexed by the N400 effect.
We used a twin study design to investigate whether N400 effect abnormalities reflect genetic/trait liability or are related to psychopathological processes in schizophrenia.
Methods.
We employed robust linear regression to compare N400 and behavioral priming effects across 36 monozygotic twin pairs (6 pairs concordant for schizophrenia/schizoaffective disorder, 11 discordant pairs, and 19 healthy control pairs) performing a lexical decision task.
Moreover, we examined the correlation between Brief Psychiatric Rating Scale (BPRS) score and the N400 effect and the influence of medication status on this effect.
Results.
Regression yielded a significant main effect of group on the N400 effect only in the direct priming condition (p=0.003).
Indirect condition and behavioral priming effect showed no significant effect of group.
Planned contrasts with the control group as a reference group revealed that affected concordant twins had significantly reduced N400 effect compared to controls, and discordant affected twins had a statistical trend for reduced N400 effect compared to controls.
The unaffected twins did not differ significantly from the controls.
There was a trend for correlation between reduced N400 effect and higher BPRS scores, and the N400 effect did not differ significantly between medicated and unmedicated patients.
Conclusions.
Reduced N400 effect may reflect disease-specific processes in schizophrenia implicating frontotemporal brain network in schizophrenia pathology.
American Psychological Association (APA)
Sharma, Anuradha& Sauer, Heinrich& Hill, Holger& Kaufmann, Claudia& Bender, Stephan& Weisbrod, Matthias. 2017. Abnormal N400 Semantic Priming Effect May Reflect Psychopathological Processes in Schizophrenia: A Twin Study. Schizophrenia Research and Treatment،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1198010
Modern Language Association (MLA)
Sharma, Anuradha…[et al.]. Abnormal N400 Semantic Priming Effect May Reflect Psychopathological Processes in Schizophrenia: A Twin Study. Schizophrenia Research and Treatment No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1198010
American Medical Association (AMA)
Sharma, Anuradha& Sauer, Heinrich& Hill, Holger& Kaufmann, Claudia& Bender, Stephan& Weisbrod, Matthias. Abnormal N400 Semantic Priming Effect May Reflect Psychopathological Processes in Schizophrenia: A Twin Study. Schizophrenia Research and Treatment. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1198010
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1198010