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Cortical Thinning in Network-Associated Regions in Cognitively Normal and Below-Normal Range Schizophrenia
Joint Authors
Heinrichs, R. Walter
Pinnock, Farena
Parlar, Melissa
Hawco, Colin
Hanford, Lindsay
Hall, Geoffrey B.
Source
Schizophrenia Research and Treatment
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-28
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
This study assessed whether cortical thickness across the brain and regionally in terms of the default mode, salience, and central executive networks differentiates schizophrenia patients and healthy controls with normal range or below-normal range cognitive performance.
Cognitive normality was defined using the MATRICS Consensus Cognitive Battery (MCCB) composite score (T=50 ± 10) and structural magnetic resonance imaging was used to generate cortical thickness data.
Whole brain analysis revealed that cognitively normal range controls (n=39) had greater cortical thickness than both cognitively normal (n=17) and below-normal range (n=49) patients.
Cognitively normal controls also demonstrated greater thickness than patients in regions associated with the default mode and salience, but not central executive networks.
No differences on any thickness measure were found between cognitively normal range and below-normal range controls (n=24) or between cognitively normal and below-normal range patients.
In addition, structural covariance between network regions was high and similar across subgroups.
Positive and negative symptom severity did not correlate with thickness values.
Cortical thinning across the brain and regionally in relation to the default and salience networks may index shared aspects of the psychotic psychopathology that defines schizophrenia with no relation to cognitive impairment.
American Psychological Association (APA)
Heinrichs, R. Walter& Pinnock, Farena& Parlar, Melissa& Hawco, Colin& Hanford, Lindsay& Hall, Geoffrey B.. 2017. Cortical Thinning in Network-Associated Regions in Cognitively Normal and Below-Normal Range Schizophrenia. Schizophrenia Research and Treatment،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1198013
Modern Language Association (MLA)
Heinrichs, R. Walter…[et al.]. Cortical Thinning in Network-Associated Regions in Cognitively Normal and Below-Normal Range Schizophrenia. Schizophrenia Research and Treatment No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1198013
American Medical Association (AMA)
Heinrichs, R. Walter& Pinnock, Farena& Parlar, Melissa& Hawco, Colin& Hanford, Lindsay& Hall, Geoffrey B.. Cortical Thinning in Network-Associated Regions in Cognitively Normal and Below-Normal Range Schizophrenia. Schizophrenia Research and Treatment. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1198013
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1198013