The Use of Endothelial Progenitor Cells for the Regeneration of Musculoskeletal and Neural Tissues
Joint Authors
Ochi, Mitsuo
Atesok, Kivanc
Kamei, Naosuke
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-28
Country of Publication
Egypt
No. of Pages
7
Abstract EN
Endothelial progenitor cells (EPCs) derived from bone marrow and blood can differentiate into endothelial cells and promote neovascularization.
In addition, EPCs are a promising cell source for the repair of various types of vascularized tissues and have been used in animal experiments and clinical trials for tissue repair.
In this review, we focused on the kinetics of endogenous EPCs during tissue repair and the application of EPCs or stem cell populations containing EPCs for tissue regeneration in musculoskeletal and neural tissues including the bone, skeletal muscle, ligaments, spinal cord, and peripheral nerves.
EPCs can be mobilized from bone marrow and recruited to injured tissue to contribute to neovascularization and tissue repair.
In addition, EPCs or stem cell populations containing EPCs promote neovascularization and tissue repair through their differentiation to endothelial cells or tissue-specific cells, the upregulation of growth factors, and the induction and activation of endogenous stem cells.
Human peripheral blood CD34(+) cells containing EPCs have been used in clinical trials of bone repair.
Thus, EPCs are a promising cell source for the treatment of musculoskeletal and neural tissue injury.
American Psychological Association (APA)
Kamei, Naosuke& Atesok, Kivanc& Ochi, Mitsuo. 2017. The Use of Endothelial Progenitor Cells for the Regeneration of Musculoskeletal and Neural Tissues. Stem Cells International،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1200865
Modern Language Association (MLA)
Kamei, Naosuke…[et al.]. The Use of Endothelial Progenitor Cells for the Regeneration of Musculoskeletal and Neural Tissues. Stem Cells International No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1200865
American Medical Association (AMA)
Kamei, Naosuke& Atesok, Kivanc& Ochi, Mitsuo. The Use of Endothelial Progenitor Cells for the Regeneration of Musculoskeletal and Neural Tissues. Stem Cells International. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1200865
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1200865