Emerging Roles of Synapse Organizers in the Regulation of Critical Periods
Joint Authors
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-09-03
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Experience remodels cortical connectivity during developmental windows called critical periods.
Experience-dependent regulation of synaptic strength during these periods establishes circuit functions that are stabilized as critical period plasticity wanes.
These processes have been extensively studied in the developing visual cortex, where critical period opening and closure are orchestrated by the assembly, maturation, and strengthening of distinct synapse types.
The synaptic specificity of these processes points towards the involvement of distinct molecular pathways.
Attractive candidates are pre- and postsynaptic transmembrane proteins that form adhesive complexes across the synaptic cleft.
These synapse-organizing proteins control synapse development and maintenance and modulate structural and functional properties of synapses.
Recent evidence suggests that they have pivotal roles in the onset and closure of the critical period for vision.
In this review, we describe roles of synapse-organizing adhesion molecules in the regulation of visual critical period plasticity and we discuss the potential they offer to restore circuit functions in amblyopia and other neurodevelopmental disorders.
American Psychological Association (APA)
Ribic, Adema& Biederer, Thomas. 2019. Emerging Roles of Synapse Organizers in the Regulation of Critical Periods. Neural Plasticity،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1200989
Modern Language Association (MLA)
Ribic, Adema& Biederer, Thomas. Emerging Roles of Synapse Organizers in the Regulation of Critical Periods. Neural Plasticity No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1200989
American Medical Association (AMA)
Ribic, Adema& Biederer, Thomas. Emerging Roles of Synapse Organizers in the Regulation of Critical Periods. Neural Plasticity. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1200989
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1200989