A Subtle Network Mediating Axon Guidance: Intrinsic Dynamic Structure of Growth Cone, Attractive and Repulsive Molecular Cues, and the Intermediate Role of Signaling Pathways
Joint Authors
Ye, Xiyue
Qiu, Yan
Gao, Yuqing
Wan, Dong
Zhu, HuiFeng
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-26, 26 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-04-14
Country of Publication
Egypt
No. of Pages
26
Main Subjects
Abstract EN
A fundamental feature of both early nervous system development and axon regeneration is the guidance of axonal projections to their targets in order to assemble neural circuits that control behavior.
In the navigation process where the nerves grow toward their targets, the growth cones, which locate at the tips of axons, sense the environment surrounding them, including varies of attractive or repulsive molecular cues, then make directional decisions to adjust their navigation journey.
The turning ability of a growth cone largely depends on its highly dynamic skeleton, where actin filaments and microtubules play a very important role in its motility.
In this review, we summarize some possible mechanisms underlying growth cone motility, relevant molecular cues, and signaling pathways in axon guidance of previous studies and discuss some questions regarding directions for further studies.
American Psychological Association (APA)
Ye, Xiyue& Qiu, Yan& Gao, Yuqing& Wan, Dong& Zhu, HuiFeng. 2019. A Subtle Network Mediating Axon Guidance: Intrinsic Dynamic Structure of Growth Cone, Attractive and Repulsive Molecular Cues, and the Intermediate Role of Signaling Pathways. Neural Plasticity،Vol. 2019, no. 2019, pp.1-26.
https://search.emarefa.net/detail/BIM-1201023
Modern Language Association (MLA)
Ye, Xiyue…[et al.]. A Subtle Network Mediating Axon Guidance: Intrinsic Dynamic Structure of Growth Cone, Attractive and Repulsive Molecular Cues, and the Intermediate Role of Signaling Pathways. Neural Plasticity No. 2019 (2019), pp.1-26.
https://search.emarefa.net/detail/BIM-1201023
American Medical Association (AMA)
Ye, Xiyue& Qiu, Yan& Gao, Yuqing& Wan, Dong& Zhu, HuiFeng. A Subtle Network Mediating Axon Guidance: Intrinsic Dynamic Structure of Growth Cone, Attractive and Repulsive Molecular Cues, and the Intermediate Role of Signaling Pathways. Neural Plasticity. 2019. Vol. 2019, no. 2019, pp.1-26.
https://search.emarefa.net/detail/BIM-1201023
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1201023