Paracrine Secreted Frizzled-Related Protein 4 Inhibits Melanocytes Differentiation in Hair Follicle
Joint Authors
Guo, Haiying
Lei, Mingxing
Li, Yuhong
Liu, Yingxin
Tang, Yinhong
Xing, Yizhan
Deng, Fang
Yang, Ke
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-27
Country of Publication
Egypt
No. of Pages
12
Abstract EN
Wnt signaling plays crucial role in regulating melanocyte stem cells/melanocyte differentiation in the hair follicle.
However, how the Wnt signaling is balanced to be overactivated to control follicular melanocytes behavior remains unknown.
Here, by using immunofluorescence staining, we showed that secreted frizzled-related protein 4 (sFRP4) is preferentially expressed in the skin epidermal cells rather than in melanocytes.
By overexpression of sFRP4 in skin cells in vivo and in vitro, we found that sFRP4 attenuates activation of Wnt signaling, resulting in decrease of melanocytes differentiation in the regenerating hair follicle.
Our findings unveiled a new regulator that involves modulating melanocytes differentiation through a paracrine mechanism in hair follicle, supplying a hope for potential therapeutic application to treat skin pigmentation disorders.
American Psychological Association (APA)
Guo, Haiying& Lei, Mingxing& Li, Yuhong& Liu, Yingxin& Tang, Yinhong& Xing, Yizhan…[et al.]. 2017. Paracrine Secreted Frizzled-Related Protein 4 Inhibits Melanocytes Differentiation in Hair Follicle. Stem Cells International،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1201048
Modern Language Association (MLA)
Guo, Haiying…[et al.]. Paracrine Secreted Frizzled-Related Protein 4 Inhibits Melanocytes Differentiation in Hair Follicle. Stem Cells International No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1201048
American Medical Association (AMA)
Guo, Haiying& Lei, Mingxing& Li, Yuhong& Liu, Yingxin& Tang, Yinhong& Xing, Yizhan…[et al.]. Paracrine Secreted Frizzled-Related Protein 4 Inhibits Melanocytes Differentiation in Hair Follicle. Stem Cells International. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1201048
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1201048