The Modulatory Effect of Cerebrovascular Burden in Response to Cognitive Stimulation in Healthy Ageing and Mild Cognitive Impairment
Joint Authors
Venneri, Annalena
De Marco, Matteo
Bentham, Charlotte
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-08-06
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Background.
Cerebrovascular burden is a common pathology in mild cognitive impairment (MCI) and Alzheimer’s disease (AD), with an additive impact on cognitive functioning.
Despite being proposed as a potential moderator of cholinesterase inhibiting drug therapy, there is a paucity of evidence investigating the impact of cerebrovascular pathology on responsiveness to cognitive interventions.
Method.
The current study uses neuropsychological, neurostructural, and functional connectivity indices to characterise response to a cognitive stimulation paradigm in 25 healthy ageing and 22 MCI participants, to examine the hypothesised detrimental effects of concurrent vascular pathology.
Results.
In both healthy ageing and MCI, increased levels of vascular pathology limited the potential for a neuroplastic response to cognitive stimulation.
In healthy ageing, participants with lower levels of vascular burden had greater functional connectivity response in the target posterior default mode network.
Those with low levels of vascular pathology in the MCI cohort had increased functional connectivity of the right insula and claustrum within the salience network.
Burden did not, however, predict cognitive or neuroanatomical changes.
Conclusions.
The current research evidences the modulatory effect of cerebrovascular pathology in interventions aimed at re-establishing network connectivity to prevent cognitive deterioration and delay the transition to the dementia stage of AD.
Examination of co-occurring vascular pathology may improve precision in targeting treatment to MCI candidates who may respond optimally to such cognitive interventions.
American Psychological Association (APA)
Bentham, Charlotte& De Marco, Matteo& Venneri, Annalena. 2019. The Modulatory Effect of Cerebrovascular Burden in Response to Cognitive Stimulation in Healthy Ageing and Mild Cognitive Impairment. Neural Plasticity،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1201050
Modern Language Association (MLA)
Bentham, Charlotte…[et al.]. The Modulatory Effect of Cerebrovascular Burden in Response to Cognitive Stimulation in Healthy Ageing and Mild Cognitive Impairment. Neural Plasticity No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1201050
American Medical Association (AMA)
Bentham, Charlotte& De Marco, Matteo& Venneri, Annalena. The Modulatory Effect of Cerebrovascular Burden in Response to Cognitive Stimulation in Healthy Ageing and Mild Cognitive Impairment. Neural Plasticity. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1201050
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1201050