Targeting Signaling Pathways in Cancer Stem Cells for Cancer Treatment
Joint Authors
Hao, Jijun
Koury, Jeffrey
Zhong, Li
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-05
Country of Publication
Egypt
No. of Pages
10
Abstract EN
The Wnt, Hedgehog, and Notch pathways are inherent signaling pathways in normal embryogenesis, development, and hemostasis.
However, dysfunctions of these pathways are evident in multiple tumor types and malignancies.
Specifically, aberrant activation of these pathways is implicated in modulation of cancer stem cells (CSCs), a small subset of cancer cells capable of self-renewal and differentiation into heterogeneous tumor cells.
The CSCs are accountable for tumor initiation, growth, and recurrence.
In this review, we focus on roles of Wnt, Hedgehog, and Notch pathways in CSCs’ stemness and functions and summarize therapeutic studies targeting these pathways to eliminate CSCs and improve overall cancer treatment outcomes.
American Psychological Association (APA)
Koury, Jeffrey& Zhong, Li& Hao, Jijun. 2017. Targeting Signaling Pathways in Cancer Stem Cells for Cancer Treatment. Stem Cells International،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1201085
Modern Language Association (MLA)
Koury, Jeffrey…[et al.]. Targeting Signaling Pathways in Cancer Stem Cells for Cancer Treatment. Stem Cells International No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1201085
American Medical Association (AMA)
Koury, Jeffrey& Zhong, Li& Hao, Jijun. Targeting Signaling Pathways in Cancer Stem Cells for Cancer Treatment. Stem Cells International. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1201085
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1201085