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Safety of Allogeneic Canine Adipose Tissue-Derived Mesenchymal Stem Cell Intraspinal Transplantation in Dogs with Chronic Spinal Cord Injury
Joint Authors
Goldenberg, Regina C. S.
Gutfilen, Bianca
Escalhão, Cláudia Cardoso Maciel
Ramos, Isalira Peroba
Hochman-Mendez, Camila
Brunswick, Tais Hanae Kasai
Coelho-Sampaio, Tatiana
Lopes de Souza, Sergio Augusto
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-22
Country of Publication
Egypt
No. of Pages
11
Abstract EN
This is a pilot clinical study primarily designed to assess the feasibility and safety of X-ray-guided percutaneous intraspinal injection of allogeneic canine adipose tissue-derived mesenchymal stem cells in dogs with chronic spinal cord injury.
Six dogs with chronic paraplegia (≥six months) were intraparenchymally injected with allogeneic cells in the site of lesion.
Cells were obtained from subcutaneous adipose tissue of a healthy dog, cultured to passage 3, labeled with 99mTechnetium, and transplanted into the lesion by percutaneous X-ray-guided injection.
Digital X-ray efficiently guided cell injection as 99mTechnetium-labeled cells remained in the injection site for at least 24 hours after transplantation.
No adverse effects or complications (infection, neuropathic pain, or worsening of neurological function) were observed during the 16-week follow-up period after transplantation.
Three animals improved locomotion as assessed by the Olby scale.
One animal walked without support, but no changes in deep pain perception were observed.
We conclude that X-ray-guided percutaneous intraspinal transplantation of allogeneic cells in dogs with chronic spinal cord injury is feasible and safe.
The efficacy of the treatment will be assessed in a new study involving a larger number of animals.
American Psychological Association (APA)
Escalhão, Cláudia Cardoso Maciel& Ramos, Isalira Peroba& Hochman-Mendez, Camila& Brunswick, Tais Hanae Kasai& Lopes de Souza, Sergio Augusto& Gutfilen, Bianca…[et al.]. 2017. Safety of Allogeneic Canine Adipose Tissue-Derived Mesenchymal Stem Cell Intraspinal Transplantation in Dogs with Chronic Spinal Cord Injury. Stem Cells International،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1201114
Modern Language Association (MLA)
Escalhão, Cláudia Cardoso Maciel…[et al.]. Safety of Allogeneic Canine Adipose Tissue-Derived Mesenchymal Stem Cell Intraspinal Transplantation in Dogs with Chronic Spinal Cord Injury. Stem Cells International No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1201114
American Medical Association (AMA)
Escalhão, Cláudia Cardoso Maciel& Ramos, Isalira Peroba& Hochman-Mendez, Camila& Brunswick, Tais Hanae Kasai& Lopes de Souza, Sergio Augusto& Gutfilen, Bianca…[et al.]. Safety of Allogeneic Canine Adipose Tissue-Derived Mesenchymal Stem Cell Intraspinal Transplantation in Dogs with Chronic Spinal Cord Injury. Stem Cells International. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1201114
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1201114