When Long Noncoding RNAs Meet Genome Editing in Pluripotent Stem Cells
Joint Authors
Chen, Fuquan
Ji, Jiaojiao
Shen, Jian
Lu, Xinyi
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-23
Country of Publication
Egypt
No. of Pages
13
Abstract EN
Most of the human genome can be transcribed into RNAs, but only a minority of these regions produce protein-coding mRNAs whereas the remaining regions are transcribed into noncoding RNAs.
Long noncoding RNAs (lncRNAs) were known for their influential regulatory roles in multiple biological processes such as imprinting, dosage compensation, transcriptional regulation, and splicing.
The physiological functions of protein-coding genes have been extensively characterized through genome editing in pluripotent stem cells (PSCs) in the past 30 years; however, the study of lncRNAs with genome editing technologies only came into attentions in recent years.
Here, we summarize recent advancements in dissecting the roles of lncRNAs with genome editing technologies in PSCs and highlight potential genome editing tools useful for examining the functions of lncRNAs in PSCs.
American Psychological Association (APA)
Chen, Fuquan& Ji, Jiaojiao& Shen, Jian& Lu, Xinyi. 2017. When Long Noncoding RNAs Meet Genome Editing in Pluripotent Stem Cells. Stem Cells International،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1201154
Modern Language Association (MLA)
Chen, Fuquan…[et al.]. When Long Noncoding RNAs Meet Genome Editing in Pluripotent Stem Cells. Stem Cells International No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1201154
American Medical Association (AMA)
Chen, Fuquan& Ji, Jiaojiao& Shen, Jian& Lu, Xinyi. When Long Noncoding RNAs Meet Genome Editing in Pluripotent Stem Cells. Stem Cells International. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1201154
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1201154