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Altered Spontaneous Brain Activity of Children with Unilateral Amblyopia: A Resting State fMRI Study
Joint Authors
Wu, Jing
Zou, Beiji
Zhang, Jinlong
Chen, Zailiang
Wu, Ying
Wei, Xin
Xiao, Manyi
Dai, Peishan
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-07-25
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Objective.
This study is aimed at investigating differences in local brain activity and functional connectivity (FC) between children with unilateral amblyopia and healthy controls (HCs) by using resting state functional magnetic resonance imaging (rs-fMRI).
Methods.
Local activity and FC analysis methods were used to explore the altered spontaneous brain activity of children with unilateral amblyopia.
Local brain function analysis methods included the amplitude of low-frequency fluctuation (ALFF).
FC analysis methods consisted of the FC between the primary visual cortex (PVC-FC) and other brain regions and the FC network between regions of interest (ROIs-FC) selected by independent component analysis.
Results.
The ALFF in the bilateral frontal, temporal, and occipital lobes in the amblyopia group was lower than that in the HCs.
The weakened PVC-FC was mainly concentrated in the frontal lobe and the angular gyrus.
The ROIs-FC between the default mode network, salience network, and primary visual cortex network (PVCN) were significantly reduced, whereas the ROIs-FC between the PVCN and the high-level visual cortex network were significantly increased in amblyopia.
Conclusions.
Unilateral amblyopia may reduce local brain activity and FC in the dorsal and ventral visual pathways and affect the top-down attentional control.
Amblyopia may also alter FC between brain functional networks.
These findings may help understand the pathological mechanisms of children with amblyopia.
American Psychological Association (APA)
Dai, Peishan& Zhang, Jinlong& Wu, Jing& Chen, Zailiang& Zou, Beiji& Wu, Ying…[et al.]. 2019. Altered Spontaneous Brain Activity of Children with Unilateral Amblyopia: A Resting State fMRI Study. Neural Plasticity،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1201182
Modern Language Association (MLA)
Dai, Peishan…[et al.]. Altered Spontaneous Brain Activity of Children with Unilateral Amblyopia: A Resting State fMRI Study. Neural Plasticity No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1201182
American Medical Association (AMA)
Dai, Peishan& Zhang, Jinlong& Wu, Jing& Chen, Zailiang& Zou, Beiji& Wu, Ying…[et al.]. Altered Spontaneous Brain Activity of Children with Unilateral Amblyopia: A Resting State fMRI Study. Neural Plasticity. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1201182
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1201182