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Guided Bone Regeneration Using Collagen Scaffolds, Growth Factors, and Periodontal Ligament Stem Cells for Treatment of Peri-Implant Bone Defects In Vivo
Joint Authors
Wegner, Katharina
Frerich, Bernhard
Kämmerer, Peer Wolfgang
Scholz, Malte
Baudisch, Maria
Liese, Jan
Lang, Hermann
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-16
Country of Publication
Egypt
No. of Pages
9
Abstract EN
Introduction.
The aim of the study was an evaluation of different approaches for guided bone regeneration (GBR) of peri-implant defects in an in vivo animal model.
Materials and Methods.
In minipigs (n=15), peri-implant defects around calcium phosphate- (CaP-; n=46) coated implants were created and randomly filled with (1) blank, (2) collagen/hydroxylapatite/β-tricalcium phosphate scaffold (CHT), (3) CHT + growth factor cocktail (GFC), (4) jellyfish collagen matrix, (5) jellyfish collagen matrix + GFC, (6) collagen powder, and (7) collagen powder + periodontal ligament stem cells (PDLSC).
Additional collagen membranes were used for coverage of the defects.
After 120 days of healing, bone growth was evaluated histologically (bone to implant contact (BIC;%)), vertical bone apposition (VBA; mm), and new bone height (NBH; %).
Results.
In all groups, new bone formation was seen.
Though, when compared to the blank group, no significant differences were detected for all parameters.
BIC and NBH in the group with collagen matrix as well as the group with the collagen matrix + GFC were significantly less when compared to the collagen powder group (all: p<0.003).
Conclusion.
GBR procedures, in combination with CaP-coated implants, will lead to an enhancement of peri-implant bone growth.
There was no additional significant enhancement of osseous regeneration when using GFC or PDLSC.
American Psychological Association (APA)
Kämmerer, Peer Wolfgang& Scholz, Malte& Baudisch, Maria& Liese, Jan& Wegner, Katharina& Frerich, Bernhard…[et al.]. 2017. Guided Bone Regeneration Using Collagen Scaffolds, Growth Factors, and Periodontal Ligament Stem Cells for Treatment of Peri-Implant Bone Defects In Vivo. Stem Cells International،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1201194
Modern Language Association (MLA)
Kämmerer, Peer Wolfgang…[et al.]. Guided Bone Regeneration Using Collagen Scaffolds, Growth Factors, and Periodontal Ligament Stem Cells for Treatment of Peri-Implant Bone Defects In Vivo. Stem Cells International No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1201194
American Medical Association (AMA)
Kämmerer, Peer Wolfgang& Scholz, Malte& Baudisch, Maria& Liese, Jan& Wegner, Katharina& Frerich, Bernhard…[et al.]. Guided Bone Regeneration Using Collagen Scaffolds, Growth Factors, and Periodontal Ligament Stem Cells for Treatment of Peri-Implant Bone Defects In Vivo. Stem Cells International. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1201194
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1201194