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Changes of Bone Turnover Markers in Long Bone Nonunions Treated with a Regenerative Approach
Joint Authors
Granchi, Donatella
Gómez-Barrena, Enrique
Rojewski, Markus
Rosset, Philippe
Layrolle, Pierre
Spazzoli, Benedetta
Donati, Davide Maria
Ciapetti, Gabriela
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-20
Country of Publication
Egypt
No. of Pages
11
Abstract EN
In this clinical trial, we investigated if biochemical bone turnover markers (BTM) changed according to the progression of bone healing induced by autologous expanded MSC combined with a biphasic calcium phosphate in patients with delayed union or nonunion of long bone fractures.
Bone formation markers, bone resorption markers, and osteoclast regulatory proteins were measured by enzymatic immunoassay before surgery and after 6, 12, and 24 weeks.
A satisfactory bone healing was obtained in 23 out of 24 patients.
Nine subjects reached a good consolidation already at 12 weeks, and they were considered as the “early consolidation” group.
We found that bone-specific alkaline phosphatase (BAP), C-terminal propeptide of type I procollagen (PICP), and beta crosslaps collagen (CTX) changed after the regenerative treatment, BAP and CTX correlated to the imaging results collected at 12 and 24 weeks, and BAP variation along the healing course differed in patients who had an “early consolidation.” A remarkable decrease in BAP and PICP was observed at all time points in a single patient who experienced a treatment failure, but the predictive value of BTM changes cannot be determined.
Our findings suggest that BTM are promising tools for monitoring cell therapy efficacy in bone nonunions, but studies with larger patient numbers are required to confirm these preliminary results.
American Psychological Association (APA)
Granchi, Donatella& Gómez-Barrena, Enrique& Rojewski, Markus& Rosset, Philippe& Layrolle, Pierre& Spazzoli, Benedetta…[et al.]. 2017. Changes of Bone Turnover Markers in Long Bone Nonunions Treated with a Regenerative Approach. Stem Cells International،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1201213
Modern Language Association (MLA)
Granchi, Donatella…[et al.]. Changes of Bone Turnover Markers in Long Bone Nonunions Treated with a Regenerative Approach. Stem Cells International No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1201213
American Medical Association (AMA)
Granchi, Donatella& Gómez-Barrena, Enrique& Rojewski, Markus& Rosset, Philippe& Layrolle, Pierre& Spazzoli, Benedetta…[et al.]. Changes of Bone Turnover Markers in Long Bone Nonunions Treated with a Regenerative Approach. Stem Cells International. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1201213
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1201213