Cancer Stem Cells and Their Microenvironment: Biology and Therapeutic Implications
Joint Authors
Lau, Eunice Yuen-Ting
Ho, Nicole Pui-Yu
Lee, Terence Kin-Wah
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-26
Country of Publication
Egypt
No. of Pages
11
Abstract EN
Tumor consists of heterogeneous cancer cells including cancer stem cells (CSCs) that can terminally differentiate into tumor bulk.
Normal stem cells in normal organs regulate self-renewal within a stem cell niche.
Likewise, accumulating evidence has also suggested that CSCs are maintained extrinsically within the tumor microenvironment, which includes both cellular and physical factors.
Here, we review the significance of stromal cells, immune cells, extracellular matrix, tumor stiffness, and hypoxia in regulation of CSC plasticity and therapeutic resistance.
With a better understanding of how CSC interacts with its niche, we are able to identify potential therapeutic targets for the development of more effective treatments against cancer.
American Psychological Association (APA)
Lau, Eunice Yuen-Ting& Ho, Nicole Pui-Yu& Lee, Terence Kin-Wah. 2017. Cancer Stem Cells and Their Microenvironment: Biology and Therapeutic Implications. Stem Cells International،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1201434
Modern Language Association (MLA)
Lau, Eunice Yuen-Ting…[et al.]. Cancer Stem Cells and Their Microenvironment: Biology and Therapeutic Implications. Stem Cells International No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1201434
American Medical Association (AMA)
Lau, Eunice Yuen-Ting& Ho, Nicole Pui-Yu& Lee, Terence Kin-Wah. Cancer Stem Cells and Their Microenvironment: Biology and Therapeutic Implications. Stem Cells International. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1201434
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1201434