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Optogenetic Stimulation Enhanced Neuronal Plasticities in Motor Recovery after Ischemic Stroke
Joint Authors
Wu, Xiang-Long
Lu, Chang-Bo
Ma, Hongzhe
Wang, Qingchuan
Wang, Yikai
Luo, Yan
Li, Cong
Xu, Hui
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-03-14
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Motor capability recovery after ischemic stroke involves dynamic remodeling processes of neural connectomes in the nervous system.
Various neuromodulatory strategies combining direct stimulating interventions with behavioral trainings for motor recovery after ischemic stroke have been developed.
However, the effectiveness of these interventions varies widely due to unspecific activation or inhibition of undefined neuronal subtypes.
Optogenetics is a functional and structural connection-based approach that can selectively activate or inhibit specific subtype neurons with a higher precision, and it has been widely applied to build up neuronal plasticities of the nervous system, which shows a great potential in restoring motor functions in stroke animal models.
Here, we reviewed neurobiological mechanisms of enhanced brain plasticities underlying motor recovery through the optogenetic stimulation after ischemic stroke.
Several brain sites and neural circuits that have been previously proven effective for motor function rehabilitation were identified, which would be helpful for a more schematic understanding of effective neuronal connectomes in the motor function recovery after ischemic stroke.
American Psychological Association (APA)
Lu, Chang-Bo& Wu, Xiang-Long& Ma, Hongzhe& Wang, Qingchuan& Wang, Yikai& Luo, Yan…[et al.]. 2019. Optogenetic Stimulation Enhanced Neuronal Plasticities in Motor Recovery after Ischemic Stroke. Neural Plasticity،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1201463
Modern Language Association (MLA)
Lu, Chang-Bo…[et al.]. Optogenetic Stimulation Enhanced Neuronal Plasticities in Motor Recovery after Ischemic Stroke. Neural Plasticity No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1201463
American Medical Association (AMA)
Lu, Chang-Bo& Wu, Xiang-Long& Ma, Hongzhe& Wang, Qingchuan& Wang, Yikai& Luo, Yan…[et al.]. Optogenetic Stimulation Enhanced Neuronal Plasticities in Motor Recovery after Ischemic Stroke. Neural Plasticity. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1201463
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1201463