Neuronal Pentraxin 2 Binds PNNs and Enhances PNN Formation
Joint Authors
Kwok, Jessica C.
Fawcett, J. W.
Haenzi, Barbara
Van’t Spijker, Heleen M.
Rowlands, Dáire
Rossier, Jean
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-10-20
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
The perineuronal net (PNN) is a mesh-like proteoglycan structure on the neuronal surface which is involved in regulating plasticity.
The PNN regulates plasticity via multiple pathways, one of which is direct regulation of synapses through the control of AMPA receptor mobility.
Since neuronal pentraxin 2 (Nptx2) is a known regulator of AMPA receptor mobility and Nptx2 can be removed from the neuronal surface by PNN removal, we investigated whether Nptx2 has a function in the PNN.
We found that Nptx2 binds to the glycosaminoglycans hyaluronan and chondroitin sulphate E in the PNN.
Furthermore, in primary cortical neuron cultures, the addition of NPTX2 to the culture medium enhances PNN formation during PNN development.
These findings suggest Nptx2 as a novel PNN binding protein with a role in the mechanism of PNN formation.
American Psychological Association (APA)
Van’t Spijker, Heleen M.& Rowlands, Dáire& Rossier, Jean& Haenzi, Barbara& Fawcett, J. W.& Kwok, Jessica C.. 2019. Neuronal Pentraxin 2 Binds PNNs and Enhances PNN Formation. Neural Plasticity،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1201526
Modern Language Association (MLA)
Van’t Spijker, Heleen M.…[et al.]. Neuronal Pentraxin 2 Binds PNNs and Enhances PNN Formation. Neural Plasticity No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1201526
American Medical Association (AMA)
Van’t Spijker, Heleen M.& Rowlands, Dáire& Rossier, Jean& Haenzi, Barbara& Fawcett, J. W.& Kwok, Jessica C.. Neuronal Pentraxin 2 Binds PNNs and Enhances PNN Formation. Neural Plasticity. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1201526
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1201526