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Efficiency of Repetitive Transcranial Direct Current Stimulation of the Dorsolateral Prefrontal Cortex in Disorders of Consciousness: A Randomized Sham-Controlled Study
Joint Authors
Wu, Min
Yu, Yamei
Luo, Lunjie
Wu, Yuehao
Gao, Jian
Ye, Xiangming
Luo, Ben-yan
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-06-11
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Conventional transcranial direct current stimulation (tDCS) targeting the left dorsolateral prefrontal cortex (DLPFC) could improve arousal in disorders of consciousness (DOC).
However, the comparative effectiveness of anodal stimulation of the left DLPFC and the electrophysiological effect of tDCS are yet to be determined.
In this randomized sham-controlled design, patients were separated into three groups (left/right anodal tDCS, sham).
Data on the clinical assessments and EEG were collected at baseline and after 2 weeks of tDCS.
The outcome at 3-month follow-up was evaluated using the Glasgow Outcome Scale-Extended.
Results showed that sessions of the left tDCS facilitated the excitability of the prefrontal cortex, whereas only one patient had a positive outcome.
Targeting the right DLPFC was less effective, merely leading to activation of the stimulation site, with no effect on the state of arousal.
Moreover, sham stimulation had minimal or no effect on any of the outcomes.
These results provide evidence for a hemispheric asymmetry of tDCS effects in patients with DOC.
Left anodal tDCS might be more effective for modulating cortical excitability compared to tDCS on the right DLPFC.
However, future studies with large sample sizes are needed to confirm these findings.
This trial is registered with NCT03809936.
American Psychological Association (APA)
Wu, Min& Yu, Yamei& Luo, Lunjie& Wu, Yuehao& Gao, Jian& Ye, Xiangming…[et al.]. 2019. Efficiency of Repetitive Transcranial Direct Current Stimulation of the Dorsolateral Prefrontal Cortex in Disorders of Consciousness: A Randomized Sham-Controlled Study. Neural Plasticity،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1201573
Modern Language Association (MLA)
Wu, Min…[et al.]. Efficiency of Repetitive Transcranial Direct Current Stimulation of the Dorsolateral Prefrontal Cortex in Disorders of Consciousness: A Randomized Sham-Controlled Study. Neural Plasticity No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1201573
American Medical Association (AMA)
Wu, Min& Yu, Yamei& Luo, Lunjie& Wu, Yuehao& Gao, Jian& Ye, Xiangming…[et al.]. Efficiency of Repetitive Transcranial Direct Current Stimulation of the Dorsolateral Prefrontal Cortex in Disorders of Consciousness: A Randomized Sham-Controlled Study. Neural Plasticity. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1201573
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1201573