De Novo Human Cardiac Myocytes for Medical Research: Promises and Challenges
Joint Authors
Liang, Wenbin
Cheng, Kang
Hamel, Veronique
Liao, Shudan
Lu, Aizhu
Zheng, Yong
Chen, Yawen
Xie, Yucai
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-20
Country of Publication
Egypt
No. of Pages
7
Abstract EN
The advent of cellular reprogramming technology has revolutionized biomedical research.
De novo human cardiac myocytes can now be obtained from direct reprogramming of somatic cells (such as fibroblasts), from induced pluripotent stem cells (iPSCs, which are reprogrammed from somatic cells), and from human embryonic stem cells (hESCs).
Such de novo human cardiac myocytes hold great promise for in vitro disease modeling and drug screening and in vivo cell therapy of heart disease.
Here, we review the technique advancements for generating de novo human cardiac myocytes.
We also discuss several challenges for the use of such cells in research and regenerative medicine, such as the immature phenotype and heterogeneity of de novo cardiac myocytes obtained with existing protocols.
We focus on the recent advancements in addressing such challenges.
American Psychological Association (APA)
Hamel, Veronique& Cheng, Kang& Liao, Shudan& Lu, Aizhu& Zheng, Yong& Chen, Yawen…[et al.]. 2017. De Novo Human Cardiac Myocytes for Medical Research: Promises and Challenges. Stem Cells International،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1201585
Modern Language Association (MLA)
Hamel, Veronique…[et al.]. De Novo Human Cardiac Myocytes for Medical Research: Promises and Challenges. Stem Cells International No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1201585
American Medical Association (AMA)
Hamel, Veronique& Cheng, Kang& Liao, Shudan& Lu, Aizhu& Zheng, Yong& Chen, Yawen…[et al.]. De Novo Human Cardiac Myocytes for Medical Research: Promises and Challenges. Stem Cells International. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1201585
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1201585