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Dissociation between Cerebellar and Cerebral Neural Activities in Humans with Long-Term Bilateral Sensorineural Hearing Loss
Joint Authors
Salvi, Richard J.
Zhang, Jian
Lu, Chun-Qiang
Luan, Ying
Xu, Xiao-Min
Jiao, Yun
Tang, Tian-Yu
Teng, Gao-Jun
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-03-27
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Abnormal neural activity in the cerebellum has been implicated in hearing impairments, but the effects of long-term hearing loss on cerebellar function are poorly understood.
To further explore the role of long-term bilateral sensorineural hearing loss on cerebellar function, we investigated hearing loss-induced changes among neural networks within cerebellar subregions and the changes in cerebellar-cerebral connectivity patterns using resting-state functional MRI.
Twenty-one subjects with long-term bilateral moderate-to-severe sensorineural hearing loss and 21 matched controls with clinically normal hearing underwent MRI scanning and a series of neuropsychological tests targeting cognition and emotion.
Voxel-wise functional connectivity (FC) analysis demonstrated decreased couplings between the cerebellum and other cerebral areas, including the temporal pole (TP), insula, supramarginal gyrus, inferior frontal gyrus (IFG), medial frontal gyrus, and thalamus, in long-term bilateral sensorineural hearing loss patients.
An ROI-wise FC analysis found weakened interregional connections within cerebellar subdivisions.
Moreover, there was a negative correlation between anxiety and FC between the left cerebellar lobe VI and left insula.
Hearing ability and anxiety scores were also correlated with FC between the left cerebellar lobe VI and left TP, as well as the right cerebellar lobule VI and left IFG.
Our results suggest that sensorineural hearing loss disrupts cerebellar-cerebral circuits, some potentially linked to anxiety, and interregional cerebellar connectivity.
The findings contribute to a growing body showing that auditory deprivation caused by cochlear hearing loss disrupts not only activity with the classical auditory pathway but also portions of the cerebellum that communicates with other cortical networks.
American Psychological Association (APA)
Xu, Xiao-Min& Jiao, Yun& Tang, Tian-Yu& Zhang, Jian& Lu, Chun-Qiang& Luan, Ying…[et al.]. 2019. Dissociation between Cerebellar and Cerebral Neural Activities in Humans with Long-Term Bilateral Sensorineural Hearing Loss. Neural Plasticity،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1201651
Modern Language Association (MLA)
Xu, Xiao-Min…[et al.]. Dissociation between Cerebellar and Cerebral Neural Activities in Humans with Long-Term Bilateral Sensorineural Hearing Loss. Neural Plasticity No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1201651
American Medical Association (AMA)
Xu, Xiao-Min& Jiao, Yun& Tang, Tian-Yu& Zhang, Jian& Lu, Chun-Qiang& Luan, Ying…[et al.]. Dissociation between Cerebellar and Cerebral Neural Activities in Humans with Long-Term Bilateral Sensorineural Hearing Loss. Neural Plasticity. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1201651
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1201651