Dissociation between Cerebellar and Cerebral Neural Activities in Humans with Long-Term Bilateral Sensorineural Hearing Loss

Joint Authors

Salvi, Richard J.
Zhang, Jian
Lu, Chun-Qiang
Luan, Ying
Xu, Xiao-Min
Jiao, Yun
Tang, Tian-Yu
Teng, Gao-Jun

Source

Neural Plasticity

Issue

Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2019-03-27

Country of Publication

Egypt

No. of Pages

10

Main Subjects

Biology
Medicine

Abstract EN

Abnormal neural activity in the cerebellum has been implicated in hearing impairments, but the effects of long-term hearing loss on cerebellar function are poorly understood.

To further explore the role of long-term bilateral sensorineural hearing loss on cerebellar function, we investigated hearing loss-induced changes among neural networks within cerebellar subregions and the changes in cerebellar-cerebral connectivity patterns using resting-state functional MRI.

Twenty-one subjects with long-term bilateral moderate-to-severe sensorineural hearing loss and 21 matched controls with clinically normal hearing underwent MRI scanning and a series of neuropsychological tests targeting cognition and emotion.

Voxel-wise functional connectivity (FC) analysis demonstrated decreased couplings between the cerebellum and other cerebral areas, including the temporal pole (TP), insula, supramarginal gyrus, inferior frontal gyrus (IFG), medial frontal gyrus, and thalamus, in long-term bilateral sensorineural hearing loss patients.

An ROI-wise FC analysis found weakened interregional connections within cerebellar subdivisions.

Moreover, there was a negative correlation between anxiety and FC between the left cerebellar lobe VI and left insula.

Hearing ability and anxiety scores were also correlated with FC between the left cerebellar lobe VI and left TP, as well as the right cerebellar lobule VI and left IFG.

Our results suggest that sensorineural hearing loss disrupts cerebellar-cerebral circuits, some potentially linked to anxiety, and interregional cerebellar connectivity.

The findings contribute to a growing body showing that auditory deprivation caused by cochlear hearing loss disrupts not only activity with the classical auditory pathway but also portions of the cerebellum that communicates with other cortical networks.

American Psychological Association (APA)

Xu, Xiao-Min& Jiao, Yun& Tang, Tian-Yu& Zhang, Jian& Lu, Chun-Qiang& Luan, Ying…[et al.]. 2019. Dissociation between Cerebellar and Cerebral Neural Activities in Humans with Long-Term Bilateral Sensorineural Hearing Loss. Neural Plasticity،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1201651

Modern Language Association (MLA)

Xu, Xiao-Min…[et al.]. Dissociation between Cerebellar and Cerebral Neural Activities in Humans with Long-Term Bilateral Sensorineural Hearing Loss. Neural Plasticity No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1201651

American Medical Association (AMA)

Xu, Xiao-Min& Jiao, Yun& Tang, Tian-Yu& Zhang, Jian& Lu, Chun-Qiang& Luan, Ying…[et al.]. Dissociation between Cerebellar and Cerebral Neural Activities in Humans with Long-Term Bilateral Sensorineural Hearing Loss. Neural Plasticity. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1201651

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1201651