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Characteristics of Human Endometrium-Derived Mesenchymal Stem Cells and Their Tropism to Endometriosis
Joint Authors
Cheng, Yan
Li, Liru
Wang, Dejun
Guo, Qiuyan
He, Yanan
Liang, Tian
Sun, Liyuan
Wang, Xiaojun
Cheng, Yulei
Zhang, Guangmei
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-06
Country of Publication
Egypt
No. of Pages
9
Abstract EN
Human endometrial tissue has become an attractive source of mesenchymal stem cells (MSCs) for cell-based therapies because these MSCs can be easily harvested and have tumour tropism as well as reduced immunogenic and inflammatory properties.
Our study aimed to obtain and characterise human endometrial mesenchymal stem cells (EMSCs) and assess their endometriosis tropism.
EMSCs were successfully isolated from the endometrium of women undergoing laparoscopy for idiopathic infertility.
The EMSCs presented a fibroblast-like morphology during culture.
Flow cytometry analyses showed that the cells were positive for the specific stem cell markers CD73, CD90, CD105, CD166, and HLA-ABC (major histocompatibility complex class I (MHC I)) but negative for CD14, CD34, CD45, and HLA-DR (MHC II).
Reverse transcription polymerase chain reaction results showed that the EMSCs expressed the stem cell marker OCT4.
The EMSCs could differentiate into osteocytes, adipocytes, and chondrocytes under certain conditions.
The EMSCs had a high tropism to endometriosis without tumourigenicity.
This study enhances the possibility of using EMSCs as drug carriers in human cell-based therapies.
Meanwhile, future research could also focus on developing targeted therapies for endometriosis.
American Psychological Association (APA)
Cheng, Yan& Li, Liru& Wang, Dejun& Guo, Qiuyan& He, Yanan& Liang, Tian…[et al.]. 2017. Characteristics of Human Endometrium-Derived Mesenchymal Stem Cells and Their Tropism to Endometriosis. Stem Cells International،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1201667
Modern Language Association (MLA)
Cheng, Yan…[et al.]. Characteristics of Human Endometrium-Derived Mesenchymal Stem Cells and Their Tropism to Endometriosis. Stem Cells International No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1201667
American Medical Association (AMA)
Cheng, Yan& Li, Liru& Wang, Dejun& Guo, Qiuyan& He, Yanan& Liang, Tian…[et al.]. Characteristics of Human Endometrium-Derived Mesenchymal Stem Cells and Their Tropism to Endometriosis. Stem Cells International. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1201667
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1201667