Nanotechnology-Based Cardiac Targeting and Direct Cardiac Reprogramming: The Betrothed
Joint Authors
Tocchetti, Carlo G.
Passaro, Fabiana
Testa, Gianluca
di Nezza, Francesca
Russo, Michele
Pirozzi, Flora
Russo, Tommaso
Bonaduce, Domenico
Pasquale, Abete
Costagliola, Ciro
Ambrosone, Luigi
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-11
Country of Publication
Egypt
No. of Pages
12
Abstract EN
Cardiovascular diseases represent the first cause of morbidity in Western countries, and chronic heart failure features a significant health care burden in developed countries.
Efforts in the attempt of finding new possible strategies for the treatment of CHF yielded several approaches based on the use of stem cells.
The discovery of direct cardiac reprogramming has unveiled a new approach to heart regeneration, allowing, at least in principle, the conversion of one differentiated cell type into another without proceeding through a pluripotent intermediate.
First developed for cancer treatment, nanotechnology-based approaches have opened new perspectives in many fields of medical research, including cardiovascular research.
Nanotechnology could allow the delivery of molecules with specific biological activity at a sustained and controlled rate in heart tissue, in a cell-specific manner.
Potentially, all the mediators and structural molecules involved in the fibrotic process could be selectively targeted by nanocarriers, but to date, only few experiences have been made in cardiac research.
This review highlights the most prominent concepts that characterize both the field of cardiac reprogramming and a nanomedicine-based approach to cardiovascular diseases, hypothesizing a possible synergy between these two very promising fields of research in the treatment of heart failure.
American Psychological Association (APA)
Passaro, Fabiana& Testa, Gianluca& Ambrosone, Luigi& Costagliola, Ciro& Tocchetti, Carlo G.& di Nezza, Francesca…[et al.]. 2017. Nanotechnology-Based Cardiac Targeting and Direct Cardiac Reprogramming: The Betrothed. Stem Cells International،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1201688
Modern Language Association (MLA)
Passaro, Fabiana…[et al.]. Nanotechnology-Based Cardiac Targeting and Direct Cardiac Reprogramming: The Betrothed. Stem Cells International No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1201688
American Medical Association (AMA)
Passaro, Fabiana& Testa, Gianluca& Ambrosone, Luigi& Costagliola, Ciro& Tocchetti, Carlo G.& di Nezza, Francesca…[et al.]. Nanotechnology-Based Cardiac Targeting and Direct Cardiac Reprogramming: The Betrothed. Stem Cells International. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1201688
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1201688