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The Crosstalk between Ovarian Cancer Stem Cell Niche and the Tumor Microenvironment
Joint Authors
Rice, Gregory E.
E. Illanes, Sebastian
Varas-Godoy, Manuel
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-27
Country of Publication
Egypt
No. of Pages
8
Abstract EN
Ovarian cancer is one of the most important causes of cancer-related death among women in the world.
Despite advances in ovarian cancer treatment, 70–80% of women who initially respond to therapy eventually relapse and die.
There is evidence that a small population of cells within the tumors called cancer stem cells (CSCs) could be responsible for treatment failure due to their enhanced chemoresistance and tumorigenicity.
These cells reside in a niche that maintains the principal properties of CSCs.
These properties are associated with the capacity of CSCs to interact with different cells of the tumor microenvironment including mesenchymal stem cells, endothelial cells, immune cells, and fibroblasts, promoting cancer progression.
This interaction can be mediated by cytokines, growth factors, lipids, and/or extracellular vesicles released in the CSC niche.
In this review, we will discuss how the interaction between ovarian CSCs and the tumor microenvironment can contribute to the maintenance of the CSC niche and consequently to tumor progression in ovarian cancer.
American Psychological Association (APA)
Varas-Godoy, Manuel& Rice, Gregory E.& E. Illanes, Sebastian. 2017. The Crosstalk between Ovarian Cancer Stem Cell Niche and the Tumor Microenvironment. Stem Cells International،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1201757
Modern Language Association (MLA)
Varas-Godoy, Manuel…[et al.]. The Crosstalk between Ovarian Cancer Stem Cell Niche and the Tumor Microenvironment. Stem Cells International No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1201757
American Medical Association (AMA)
Varas-Godoy, Manuel& Rice, Gregory E.& E. Illanes, Sebastian. The Crosstalk between Ovarian Cancer Stem Cell Niche and the Tumor Microenvironment. Stem Cells International. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1201757
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1201757