Paracrine Effects of Bone Marrow Mononuclear Cells in Survival and Cytokine Expression after 90% Partial Hepatectomy
Joint Authors
Matte, Ursula
Uribe-Cruz, Carolina
López, Mónica Luján
Osvaldt, Alessandro
Silveira, Themis Reverbel da
Kieling, Carlos Oscar
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-23
Country of Publication
Egypt
No. of Pages
8
Abstract EN
Acute liver failure is a complex and fatal disease.
Cell-based therapies are a promising alternative therapeutic approach for liver failure due to relatively simple technique and lower cost.
The use of semipermeable microcapsules has become an interesting tool for evaluating paracrine effects in vivo.
In this study, we aimed to assess the paracrine effects of bone marrow mononuclear cells (BMMC) encapsulated in sodium alginate to treat acute liver failure in an animal model of 90% partial hepatectomy (90% PH).
Encapsulated BMMC were able to increase 10-day survival without enhancing liver regeneration markers.
Gene expression of Il-6 and Il-10 in the remnant liver was markedly reduced at 6 h after 90% PH in animals receiving encapsulated BMMC compared to controls.
This difference, however, was neither reflected by changes in the number of CD68+ cells nor by serum levels of IL6.
On the other hand, treated animals presented increased caspase activity and gene expression in the liver.
Taken together, these results suggest that BMMC regulate immune response and promote apoptosis in the liver after 90% PH by paracrine factors.
These changes ultimately may be related to the higher survival observed in treated animals, suggesting that BMMC may be a promising alternative to treat acute liver failure.
American Psychological Association (APA)
Kieling, Carlos Oscar& Uribe-Cruz, Carolina& López, Mónica Luján& Osvaldt, Alessandro& Silveira, Themis Reverbel da& Matte, Ursula. 2017. Paracrine Effects of Bone Marrow Mononuclear Cells in Survival and Cytokine Expression after 90% Partial Hepatectomy. Stem Cells International،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1201761
Modern Language Association (MLA)
Kieling, Carlos Oscar…[et al.]. Paracrine Effects of Bone Marrow Mononuclear Cells in Survival and Cytokine Expression after 90% Partial Hepatectomy. Stem Cells International No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1201761
American Medical Association (AMA)
Kieling, Carlos Oscar& Uribe-Cruz, Carolina& López, Mónica Luján& Osvaldt, Alessandro& Silveira, Themis Reverbel da& Matte, Ursula. Paracrine Effects of Bone Marrow Mononuclear Cells in Survival and Cytokine Expression after 90% Partial Hepatectomy. Stem Cells International. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1201761
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1201761