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Direct Oral Anticoagulants in Patients Undergoing Urgent Reperfusion for Nonvalvular Atrial Fibrillation-Related Ischemic Stroke: A Brief Report on Literature Evidence
Joint Authors
Grifoni, Elisa
Dei, Alessandro
Vannucchi, Vieri
Moroni, Federico
Panigada, Grazia
Nicotra, Costanza
Spolveri, Stefano
Landini, Giancarlo
Masotti, L.
Source
Neurology Research International
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-02-24
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Introduction.
The optimal timing for starting anticoagulation in the early phase of nonvalvular atrial fibrillation (NVAF)-related acute ischemic stroke (AIS) remains a challenge, especially in patients undergoing urgent reperfusion by systemic thrombolysis or mechanical thrombectomy.
The aim of our study was to review the literature evidence reporting on safety of direct oral anticoagulants (DOACs) starting in the early phase of NVAF-related AIS undergoing systemic thrombolysis and/or mechanical thrombectomy.
Materials and Methods.
We reviewed the PubMed databases searching articles reporting on efficacy and safety of DOACs starting time within two weeks from AIS onset in patients undergoing systemic thrombolysis and/or mechanical thrombectomy.
Results.
Three studies were selected, overall including one hundred and six patients (62 females, 58.4%).
Median National Institute of Health Stroke Scale (NIHSS) score at hospital admission ranged from 9 to 13 points.
Median DOACs starting time ranged from 2 to 6 days.
Median CHA2DS2-VASC score ranged from 4 to 6 points.
Follow-up was limited to 14 days in one study, 30 days in another, and 90 days in a third one.
Overall, stroke recurrence and/or intracranial bleeding occurred in two patients (1.9%) and no patient died at follow-up.
Conclusion.
Small sample size real life studies seem to demonstrate that the introduction of DOACs in the early phase of NVAF-related AIS undergoing urgent reperfusion is efficacious and safe.
Prospective RCTs are necessary to confirm these findings.
American Psychological Association (APA)
Masotti, L.& Grifoni, Elisa& Dei, Alessandro& Vannucchi, Vieri& Moroni, Federico& Panigada, Grazia…[et al.]. 2019. Direct Oral Anticoagulants in Patients Undergoing Urgent Reperfusion for Nonvalvular Atrial Fibrillation-Related Ischemic Stroke: A Brief Report on Literature Evidence. Neurology Research International،Vol. 2019, no. 2019, pp.1-4.
https://search.emarefa.net/detail/BIM-1201773
Modern Language Association (MLA)
Masotti, L.…[et al.]. Direct Oral Anticoagulants in Patients Undergoing Urgent Reperfusion for Nonvalvular Atrial Fibrillation-Related Ischemic Stroke: A Brief Report on Literature Evidence. Neurology Research International No. 2019 (2019), pp.1-4.
https://search.emarefa.net/detail/BIM-1201773
American Medical Association (AMA)
Masotti, L.& Grifoni, Elisa& Dei, Alessandro& Vannucchi, Vieri& Moroni, Federico& Panigada, Grazia…[et al.]. Direct Oral Anticoagulants in Patients Undergoing Urgent Reperfusion for Nonvalvular Atrial Fibrillation-Related Ischemic Stroke: A Brief Report on Literature Evidence. Neurology Research International. 2019. Vol. 2019, no. 2019, pp.1-4.
https://search.emarefa.net/detail/BIM-1201773
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1201773