Cell Therapy for Refractory Angina: A Reappraisal
Joint Authors
Bassetti, Beatrice
Cavallotti, Laura
Pompilio, Giulio
Catto, Valentina
Righetti, Stefano
Achilli, Felice
Scacciatella, Paolo
Carbucicchio, Corrado
Nigro, P.
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-10
Country of Publication
Egypt
No. of Pages
11
Abstract EN
Cardiac cell-based therapy has emerged as a novel therapeutic option for patients dealing with untreatable refractory angina (RA).
However, after more than a decade of controlled studies, no definitive consensus has been reached regarding clinical efficacy.
Although positive results in terms of surrogate endpoints have been suggested by early and phase II clinical studies as well as by meta-analyses, the more recent reports lacked the provision of definitive response in terms of hard clinical endpoints.
Regrettably, pivotal trials designed to conclusively determine the efficacy of cell-based therapeutics in such a challenging clinical condition are therefore still missing.
Considering this, a comprehensive reappraisal of cardiac cell-based therapy role in RA seems warranted and timely, since a number of crucial cell- and patient-related aspects need to be systematically analysed.
As an example, the large variability in efficacy endpoint selection appears to be a limiting factor for the advancement of cardiac cell-based therapy in the field.
This review will provide an overview of the key elements that may have influenced the results of cell-based trials in the context of RA, focusing in particular on the understanding at which the extent of angina-related endpoints may predict cell-based therapeutic efficacy.
American Psychological Association (APA)
Bassetti, Beatrice& Nigro, P.& Catto, Valentina& Cavallotti, Laura& Righetti, Stefano& Achilli, Felice…[et al.]. 2017. Cell Therapy for Refractory Angina: A Reappraisal. Stem Cells International،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1201777
Modern Language Association (MLA)
Bassetti, Beatrice…[et al.]. Cell Therapy for Refractory Angina: A Reappraisal. Stem Cells International No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1201777
American Medical Association (AMA)
Bassetti, Beatrice& Nigro, P.& Catto, Valentina& Cavallotti, Laura& Righetti, Stefano& Achilli, Felice…[et al.]. Cell Therapy for Refractory Angina: A Reappraisal. Stem Cells International. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1201777
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1201777