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Protective Effects of Chronic Intermittent Hypobaric Hypoxia Pretreatment against Aplastic Anemia through Improving the Adhesiveness and Stress of Mesenchymal Stem Cells in Rats
Joint Authors
Wang, Handong
Yang, Jing
Zhang, Li
Guo, Zan
Liu, Yixian
Zhang, Yi
Wang, Chuan
Li, Quanhai
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-16
Country of Publication
Egypt
No. of Pages
13
Abstract EN
Aplastic anemia (AA) is a common malignant blood disease, and chronic intermittent hypobaric hypoxia (CIHH) has a beneficial effect against different diseases.
The aim of the present study was to investigate the protective effect of CIHH against AA and underlying mechanisms.
5-Fluorouracil and busulfan treatment induced AA model in rats with reduction of hematological parameters and bone marrow tissue injury and decrease of the colony numbers of progenitor cells.
CIHH pretreatment significantly reduced the incidence rate of AA and alleviated above symptoms in AA model.
The adhesive molecules of bone marrow mesenchymal stem cells (BMMSCs) in AA model, VLA-4, VCAM-1, and ICAM-1 were upregulated, and those of CD162 and CD164 were downregulated by CIHH pretreatment.
The expressions of HIF-1α and NF-κB in BMMSCs were also decreased through CIHH pretreatment.
Overall, the results demonstrated for the first time that CIHH has an anti-AA effect through improving the adhesiveness and stress of mesenchymal stem cells in rats.
CIHH could be a promising and effective therapy for AA.
American Psychological Association (APA)
Yang, Jing& Zhang, Li& Wang, Handong& Guo, Zan& Liu, Yixian& Zhang, Yi…[et al.]. 2017. Protective Effects of Chronic Intermittent Hypobaric Hypoxia Pretreatment against Aplastic Anemia through Improving the Adhesiveness and Stress of Mesenchymal Stem Cells in Rats. Stem Cells International،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1201786
Modern Language Association (MLA)
Yang, Jing…[et al.]. Protective Effects of Chronic Intermittent Hypobaric Hypoxia Pretreatment against Aplastic Anemia through Improving the Adhesiveness and Stress of Mesenchymal Stem Cells in Rats. Stem Cells International No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1201786
American Medical Association (AMA)
Yang, Jing& Zhang, Li& Wang, Handong& Guo, Zan& Liu, Yixian& Zhang, Yi…[et al.]. Protective Effects of Chronic Intermittent Hypobaric Hypoxia Pretreatment against Aplastic Anemia through Improving the Adhesiveness and Stress of Mesenchymal Stem Cells in Rats. Stem Cells International. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1201786
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1201786