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Lymphocytes in Placental Tissues: Immune Regulation and Translational Possibilities for Immunotherapy
Joint Authors
Uhlin, M.
Stikvoort, Arwen
Erkers, Tom
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-19
Country of Publication
Egypt
No. of Pages
17
Abstract EN
Immune modulation at the fetomaternal interface is crucial to ensure that the fetal allograft is not rejected.
In the present review, the focus is to describe basic functions of lymphocyte populations and how they may contribute to fetomaternal immune regulation, as well as determining what proportions and effector functions of these cells are reported to be present in placental tissues in humans.
Also explored is the possibility that unique cell populations at the fetomaternal interface may be targets for adoptive cell therapy.
Increasing the understanding of immune modulation during pregnancy can give valuable insight into other established fields such as allogeneic hematopoietic stem cell transplantation and solid organ transplantation.
In these settings, lymphocytes are key components that contribute to inflammation and rejection of either patient or donor tissues following transplantation.
In contrast, an allogeneic fetus eludes rejection by the maternal immune system.
American Psychological Association (APA)
Erkers, Tom& Stikvoort, Arwen& Uhlin, M.. 2017. Lymphocytes in Placental Tissues: Immune Regulation and Translational Possibilities for Immunotherapy. Stem Cells International،Vol. 2017, no. 2017, pp.1-17.
https://search.emarefa.net/detail/BIM-1201803
Modern Language Association (MLA)
Erkers, Tom…[et al.]. Lymphocytes in Placental Tissues: Immune Regulation and Translational Possibilities for Immunotherapy. Stem Cells International No. 2017 (2017), pp.1-17.
https://search.emarefa.net/detail/BIM-1201803
American Medical Association (AMA)
Erkers, Tom& Stikvoort, Arwen& Uhlin, M.. Lymphocytes in Placental Tissues: Immune Regulation and Translational Possibilities for Immunotherapy. Stem Cells International. 2017. Vol. 2017, no. 2017, pp.1-17.
https://search.emarefa.net/detail/BIM-1201803
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1201803