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Targeting Adult Neurogenesis for Poststroke Therapy
Joint Authors
Lu, Jianfei
Manaenko, Anatol
Hu, Qin
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-20
Country of Publication
Egypt
No. of Pages
10
Abstract EN
Adult neurogenesis mainly occurs at the subventricular zone (SVZ) on the walls of the lateral ventricle and the subgranular zone (SGZ) of the dentate gyrus (DG).
However, the majority of newborn neurons undergo programmed cell death (PCD) during the period of proliferation, migration, and integration.
Stroke activates neural stem cells (NSCs) in both SVZ and SGZ.
This process is regulated by a wide variety of signaling pathways.
However, the newborn neurons derived from adult neurogenesis are insufficient for tissue repair and function recovery.
Thus, enhancing the endogenous neurogenesis driven by ischemia and promoting the survival of newborn neurons can be promising therapeutic interventions for stroke.
Here, we present an overview of the process of adult neurogenesis and the potential of stroke-induced neurogenesis on brain repair.
American Psychological Association (APA)
Lu, Jianfei& Manaenko, Anatol& Hu, Qin. 2017. Targeting Adult Neurogenesis for Poststroke Therapy. Stem Cells International،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1201871
Modern Language Association (MLA)
Lu, Jianfei…[et al.]. Targeting Adult Neurogenesis for Poststroke Therapy. Stem Cells International No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1201871
American Medical Association (AMA)
Lu, Jianfei& Manaenko, Anatol& Hu, Qin. Targeting Adult Neurogenesis for Poststroke Therapy. Stem Cells International. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1201871
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1201871