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Mesenchymal Stem Cells for Cartilage Regeneration of TMJ Osteoarthritis
Joint Authors
Xu, Xin
Ye, Ling
Zhou, Xuedong
Zheng, Liwei
Cui, Dixin
Li, Hongyu
Zhou, Yachuan
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-16
Country of Publication
Egypt
No. of Pages
11
Abstract EN
Temporomandibular joint osteoarthritis (TMJ OA) is a degenerative disease, characterized by progressive cartilage degradation, subchondral bone remodeling, synovitis, and chronic pain.
Due to the limited self-healing capacity in condylar cartilage, traditional clinical treatments have limited symptom-modifying and structure-modifying effects to restore impaired cartilage as well as other TMJ tissues.
In recent years, stem cell-based therapy has raised much attention as an alternative approach towards tissue repair and regeneration.
Mesenchymal stem cells (MSCs), derived from the bone marrow, synovium, and even umbilical cord, play a role as seed cells for the cartilage regeneration of TMJ OA.
MSCs possess multilineage differentiation potential, including chondrogenic differentiation as well as osteogenic differentiation.
In addition, the trophic modulations of MSCs exert anti-inflammatory and immunomodulatory effects under aberrant conditions.
Furthermore, MSCs combined with appropriate scaffolds can form cartilaginous or even osseous compartments to repair damaged tissue and impaired function of TMJ.
In this review, we will briefly discuss the pathogenesis of cartilage degeneration in TMJ OA and emphasize the potential sources of MSCs and novel approaches for the cartilage regeneration of TMJ OA, particularly focusing on the MSC-based therapy and tissue engineering.
American Psychological Association (APA)
Cui, Dixin& Li, Hongyu& Xu, Xin& Ye, Ling& Zhou, Xuedong& Zheng, Liwei…[et al.]. 2017. Mesenchymal Stem Cells for Cartilage Regeneration of TMJ Osteoarthritis. Stem Cells International،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1201897
Modern Language Association (MLA)
Cui, Dixin…[et al.]. Mesenchymal Stem Cells for Cartilage Regeneration of TMJ Osteoarthritis. Stem Cells International No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1201897
American Medical Association (AMA)
Cui, Dixin& Li, Hongyu& Xu, Xin& Ye, Ling& Zhou, Xuedong& Zheng, Liwei…[et al.]. Mesenchymal Stem Cells for Cartilage Regeneration of TMJ Osteoarthritis. Stem Cells International. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1201897
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1201897