Targeting Cancer Stem Cells and Their Niche: Current Therapeutic Implications and Challenges in Pancreatic Cancer
Joint Authors
Zhao, Jiangang
Li, Jiahui
Schlößer, Hans A.
Popp, Felix
Popp, Marie Christine
Alakus, Hakan
Jauch, Karl-Walter
Bruns, Christiane J.
Zhao, Yue
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-06
Country of Publication
Egypt
No. of Pages
9
Abstract EN
Cancer stem cells (CSCs) have been identified as a subpopulation of stem-like cancer cells with the ability of self-renewal and differentiation in hematological malignancies and solid tumors.
Pancreatic cancer is one of the most lethal cancers worldwide.
CSCs are thought to be responsible for cancer initiation, progression, metastasis, chemoresistance, and recurrence in pancreatic cancer.
In this review, we summarize the characteristics of pancreatic CSCs and discuss the mechanisms involved in resistance to chemotherapy, the interactions with the niche, and the potential role in cancer immunoediting.
We propose that immunotherapy targeting pancreatic CSCs, in combination with targeting the niche components, may provide a novel treatment strategy to eradicate pancreatic CSCs and hence improve outcomes in pancreatic cancer.
American Psychological Association (APA)
Zhao, Jiangang& Li, Jiahui& Schlößer, Hans A.& Popp, Felix& Popp, Marie Christine& Alakus, Hakan…[et al.]. 2017. Targeting Cancer Stem Cells and Their Niche: Current Therapeutic Implications and Challenges in Pancreatic Cancer. Stem Cells International،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1201903
Modern Language Association (MLA)
Zhao, Jiangang…[et al.]. Targeting Cancer Stem Cells and Their Niche: Current Therapeutic Implications and Challenges in Pancreatic Cancer. Stem Cells International No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1201903
American Medical Association (AMA)
Zhao, Jiangang& Li, Jiahui& Schlößer, Hans A.& Popp, Felix& Popp, Marie Christine& Alakus, Hakan…[et al.]. Targeting Cancer Stem Cells and Their Niche: Current Therapeutic Implications and Challenges in Pancreatic Cancer. Stem Cells International. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1201903
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1201903