Human Long Noncoding RNA Regulation of Stem Cell Potency and Differentiation

Joint Authors

Hwang, Ki-Chul
Lee, Seahyoung
Seo, Hyang-Hee
Lee, Chang Youn
Lee, Jiyun
Shin, Sunhye
Kim, Sang Woo
Lim, Soyeon

Source

Stem Cells International

Issue

Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2017-08-30

Country of Publication

Egypt

No. of Pages

10

Abstract EN

Because of their capability of differentiation into lineage-specific cells, stem cells are an attractive therapeutic modality in regenerative medicine.

To develop an effective stem cell-based therapeutic strategy with predictable results, deeper understanding of the underlying molecular mechanisms of stem cell differentiation and/or pluripotency maintenance is required.

Thus, reviewing the key factors involved in the transcriptional and epigenetic regulation of stem cell differentiation and maintenance is important.

Accumulating data indicate that long noncoding RNAs (lncRNAs) mediate numerous biological processes, including stem cell differentiation and maintenance.

Here, we review recent findings on the human lncRNA regulation of stem cell potency and differentiation.

Although the clinical implication of these lncRNAs is only beginning to be elucidated, it is anticipated that lncRNAs will become important therapeutic targets in the near future.

American Psychological Association (APA)

Lee, Seahyoung& Seo, Hyang-Hee& Lee, Chang Youn& Lee, Jiyun& Shin, Sunhye& Kim, Sang Woo…[et al.]. 2017. Human Long Noncoding RNA Regulation of Stem Cell Potency and Differentiation. Stem Cells International،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1201966

Modern Language Association (MLA)

Lee, Seahyoung…[et al.]. Human Long Noncoding RNA Regulation of Stem Cell Potency and Differentiation. Stem Cells International No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1201966

American Medical Association (AMA)

Lee, Seahyoung& Seo, Hyang-Hee& Lee, Chang Youn& Lee, Jiyun& Shin, Sunhye& Kim, Sang Woo…[et al.]. Human Long Noncoding RNA Regulation of Stem Cell Potency and Differentiation. Stem Cells International. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1201966

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1201966