Influence of the Type of Delivery, Use of Oxytocin, and Maternal Age on POU5F1 Gene Expression in Stem Cells Derived from Wharton’s Jelly within the Umbilical Cord
Joint Authors
Rahnama, Mansur
Kocki, Janusz
Gil-Kulik, Paulina
Chomik, Piotr
Krzyżanowski, Arkadiusz
Radzikowska-Büchner, Elżbieta
Maciejewski, Ryszard
Kwaśniewska, Anna
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-12-14
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The paper presents an evaluation of the POU5F1 gene expression in mesenchymal stem cells derived from Wharton’s jelly within the umbilical cord, collected from 36 patients during labor.
The study is the first one to show that the expression of POU5F1 in mesenchymal stem cells has been dependent on maternal age, birth order, route of delivery, and use of oxytocin.
Our research proves that the POU5F1 gene expression in mesenchymal stem cells decreases with each subsequent pregnancy and delivery.
Wharton’s jelly stem cells obtained from younger women and during their first delivery, as well as patients treated with oxytocin, show higher POU5F1 gene expression when compared with the subsequent deliveries.
This leads to a conclusion that they are characterized by a lower level of differentiation, which in turn results in their greater plasticity and greater proliferative potential.
Probably, they are also clinically more useful.
American Psychological Association (APA)
Gil-Kulik, Paulina& Chomik, Piotr& Krzyżanowski, Arkadiusz& Radzikowska-Büchner, Elżbieta& Maciejewski, Ryszard& Kwaśniewska, Anna…[et al.]. 2019. Influence of the Type of Delivery, Use of Oxytocin, and Maternal Age on POU5F1 Gene Expression in Stem Cells Derived from Wharton’s Jelly within the Umbilical Cord. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1201994
Modern Language Association (MLA)
Gil-Kulik, Paulina…[et al.]. Influence of the Type of Delivery, Use of Oxytocin, and Maternal Age on POU5F1 Gene Expression in Stem Cells Derived from Wharton’s Jelly within the Umbilical Cord. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1201994
American Medical Association (AMA)
Gil-Kulik, Paulina& Chomik, Piotr& Krzyżanowski, Arkadiusz& Radzikowska-Büchner, Elżbieta& Maciejewski, Ryszard& Kwaśniewska, Anna…[et al.]. Influence of the Type of Delivery, Use of Oxytocin, and Maternal Age on POU5F1 Gene Expression in Stem Cells Derived from Wharton’s Jelly within the Umbilical Cord. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1201994
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1201994