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Safety of Cultivated Limbal Epithelial Stem Cell Transplantation for Human Corneal Regeneration
Joint Authors
Ní Dhubhghaill, Sorcha
Koppen, Carina
Zakaria, Nadia
Behaegel, J.
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-30
Country of Publication
Egypt
No. of Pages
11
Abstract EN
Ex vivo cultivated limbal stem cell transplantation is a promising technique for the treatment of limbal stem cell deficiency.
While the results of the clinical trials have been extensively reported since the introduction of the technique in 1997, little has been reported regarding the potential health risks associated with production processes and transplantation techniques.
Culture procedures require the use of animal and/or human-derived products, which carry the potential of introducing toxic or infectious agents through contamination with known or unknown additives.
Protocols vary widely, and the risks depend on the local institutional methods.
Good manufacturing practice and xeno-free culture protocols could reduce potential health risks but are not yet a common practice worldwide.
In this review, we focus on the safety of both autologous- and allogeneic-cultivated limbal stem cell transplantation, with respect to culture processes, surgical approaches, and postoperative strategies.
American Psychological Association (APA)
Behaegel, J.& Ní Dhubhghaill, Sorcha& Koppen, Carina& Zakaria, Nadia. 2017. Safety of Cultivated Limbal Epithelial Stem Cell Transplantation for Human Corneal Regeneration. Stem Cells International،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1202010
Modern Language Association (MLA)
Behaegel, J.…[et al.]. Safety of Cultivated Limbal Epithelial Stem Cell Transplantation for Human Corneal Regeneration. Stem Cells International No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1202010
American Medical Association (AMA)
Behaegel, J.& Ní Dhubhghaill, Sorcha& Koppen, Carina& Zakaria, Nadia. Safety of Cultivated Limbal Epithelial Stem Cell Transplantation for Human Corneal Regeneration. Stem Cells International. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1202010
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1202010