BMP4LIF or RAForskolin Suppresses the Proliferation of Neural Stem Cells Derived from Adult Monkey Brain
Joint Authors
Yu, Liming
Ren, Jie
Lu, Lixia
Tian, Haibin
Chen, Li
Zhang, Ying
Liu, Yuehua
Gao, Zhengliang
Han, Xin-Xin
Chen, Qingqing
Wang, Min
Wang, Guangming
Chen, Yihong
He, Hua
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-09-20
Country of Publication
Egypt
No. of Pages
11
Abstract EN
Monkeys are much closer to human and are the most common nonhuman primates which are used in biomedical studies.
Neural progenitor cells can originate from the hippocampus of adult monkeys.
Despite a few reports, the detailed properties of monkey neural stem cells (NSCs) and their responses to cytokine are still unclear.
Here, we derive NSCs from an adult monkey brain and demonstrate that BMP4 inhibits cell proliferation and affects cell morphology of monkey NSCs.
Combined treatment of BMP4 and LIF or RA and Forskolin represses the proliferation of monkey NSCs.
We also show that BMP4 may promote monkey NSC quiescence.
Our study therefore provides implications for NSC-based cell therapy of brain injury in the future.
American Psychological Association (APA)
Han, Xin-Xin& Yu, Liming& Chen, Qingqing& Wang, Min& Ren, Jie& Wang, Guangming…[et al.]. 2017. BMP4LIF or RAForskolin Suppresses the Proliferation of Neural Stem Cells Derived from Adult Monkey Brain. Stem Cells International،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1202018
Modern Language Association (MLA)
Han, Xin-Xin…[et al.]. BMP4LIF or RAForskolin Suppresses the Proliferation of Neural Stem Cells Derived from Adult Monkey Brain. Stem Cells International No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1202018
American Medical Association (AMA)
Han, Xin-Xin& Yu, Liming& Chen, Qingqing& Wang, Min& Ren, Jie& Wang, Guangming…[et al.]. BMP4LIF or RAForskolin Suppresses the Proliferation of Neural Stem Cells Derived from Adult Monkey Brain. Stem Cells International. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1202018
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1202018