Nanog Dynamics in Mouse Embryonic Stem Cells: Results from Systems Biology Approaches
Author
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-08
Country of Publication
Egypt
No. of Pages
14
Abstract EN
Mouse embryonic stem cells (mESCs), derived from the inner cell mass of the blastocyst, are pluripotent stem cells having self-renewal capability and the potential of differentiating into every cell type under the appropriate culture conditions.
An increasing number of reports have been published to uncover the molecular mechanisms that orchestrate pluripotency and cell fate specification using combined computational and experimental methodologies.
Here, we review recent systems biology approaches to describe the causes and functions of gene expression heterogeneity and complex temporal dynamics of pluripotency markers in mESCs under uniform culture conditions.
In particular, we focus on the dynamics of Nanog, a key regulator of the core pluripotency network and of mESC fate.
We summarize the strengths and limitations of different experimental and modeling approaches and discuss how various strategies could be used.
American Psychological Association (APA)
Marucci, Lucia. 2017. Nanog Dynamics in Mouse Embryonic Stem Cells: Results from Systems Biology Approaches. Stem Cells International،Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1202038
Modern Language Association (MLA)
Marucci, Lucia. Nanog Dynamics in Mouse Embryonic Stem Cells: Results from Systems Biology Approaches. Stem Cells International No. 2017 (2017), pp.1-14.
https://search.emarefa.net/detail/BIM-1202038
American Medical Association (AMA)
Marucci, Lucia. Nanog Dynamics in Mouse Embryonic Stem Cells: Results from Systems Biology Approaches. Stem Cells International. 2017. Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1202038
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1202038