Sestrins at the Interface of ROS Control and Autophagy Regulation in Health and Disease
Joint Authors
Cordani, Marco
Donadelli, Massimo
Bazhin, Alexandr V.
Strippoli, Raffaele
Sánchez-Álvarez, Miguel
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-05-07
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Reactive oxygen species (ROS) and autophagy are two highly complex and interrelated components of cell physiopathology, but our understanding of their integration and their contribution to cell homeostasis and disease is still limited.
Sestrins (SESNs) belong to a family of highly conserved stress-inducible proteins that orchestrate antioxidant and autophagy-regulating functions protecting cells from various noxious stimuli, including DNA damage, oxidative stress, hypoxia, and metabolic stress.
They are also relevant modulators of metabolism as positive regulators of the key energy sensor AMP-dependent protein kinase (AMPK) and inhibitors of mammalian target of rapamycin complex 1 (mTORC1).
Since perturbations in these pathways are central to multiple disorders, SESNs might constitute potential novel therapeutic targets of broad interest.
In this review, we discuss the current understanding of regulatory and effector networks of SESNs, highlighting their significance as potential biomarkers and therapeutic targets for different diseases, such as aging-related diseases, metabolic disorders, neurodegenerative diseases, and cancer.
American Psychological Association (APA)
Cordani, Marco& Sánchez-Álvarez, Miguel& Strippoli, Raffaele& Bazhin, Alexandr V.& Donadelli, Massimo. 2019. Sestrins at the Interface of ROS Control and Autophagy Regulation in Health and Disease. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1202077
Modern Language Association (MLA)
Cordani, Marco…[et al.]. Sestrins at the Interface of ROS Control and Autophagy Regulation in Health and Disease. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1202077
American Medical Association (AMA)
Cordani, Marco& Sánchez-Álvarez, Miguel& Strippoli, Raffaele& Bazhin, Alexandr V.& Donadelli, Massimo. Sestrins at the Interface of ROS Control and Autophagy Regulation in Health and Disease. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1202077
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1202077