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Effect of Telmisartan in the Oxidative Stress Components Induced by Ischemia Reperfusion in Rats
Joint Authors
Cardona-Muñoz, Ernesto German
Garcia-Cobian, Teresa
Miranda-Díaz, Alejandra Guillermina
Rodríguez-Lara, Simón Quetzalcoatl
García-Benavides, Leonel
Totsuka-Sutto, Sylvia E.
Trujillo-Rangel, Walter Angel
Castillo-Romero, Araceli
Ramírez-Lizardo, Ernesto Javier
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-07-02
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
The therapeutic effects of telmisartan, an angiotensin II receptor antagonist and a peroxisome proliferator-activated receptor-γ (PPAR-γ) agonist, have been demonstrated in several disorders.
It has antioxidant and immune response modulator properties and has shown promising results in the treatment of an ischemia/reperfusion (I/R) lesion.
In this study, a skeletal muscle (right gastrocnemius muscle) I/R lesion was induced in rats and different reperfusion times (1 h, 24 h, 72 h, 7-day, and 14-day subgroups) were assessed.
Furthermore, levels of oxidative markers such as enzymatic scavengers (catalase (CAT) and superoxide dismutase (SOD)) and metabolites (nitrates and 8-oxo-deoxyguanosine) were determined.
The degree of tissue injury (total lesioned fibers and inflammatory cell count) was also evaluated.
We observed an increase in CAT and SOD expression levels under telmisartan treatment, with a decrease in injury and oxidative biomarker levels in the 72 h, 7-day, and 14-day subgroups.
Telmisartan reduced oxidative stress and decreased the damage of the I/R lesion.
American Psychological Association (APA)
Rodríguez-Lara, Simón Quetzalcoatl& Trujillo-Rangel, Walter Angel& Castillo-Romero, Araceli& Totsuka-Sutto, Sylvia E.& Garcia-Cobian, Teresa& Cardona-Muñoz, Ernesto German…[et al.]. 2019. Effect of Telmisartan in the Oxidative Stress Components Induced by Ischemia Reperfusion in Rats. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1202118
Modern Language Association (MLA)
Rodríguez-Lara, Simón Quetzalcoatl…[et al.]. Effect of Telmisartan in the Oxidative Stress Components Induced by Ischemia Reperfusion in Rats. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1202118
American Medical Association (AMA)
Rodríguez-Lara, Simón Quetzalcoatl& Trujillo-Rangel, Walter Angel& Castillo-Romero, Araceli& Totsuka-Sutto, Sylvia E.& Garcia-Cobian, Teresa& Cardona-Muñoz, Ernesto German…[et al.]. Effect of Telmisartan in the Oxidative Stress Components Induced by Ischemia Reperfusion in Rats. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1202118
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1202118