Cardiac Progenitor Cells and the Interplay with Their Microenvironment
Joint Authors
Mauretti, Arianna
Spaans, Sergio
Bax, Noortje A. M.
Sahlgren, Cecilia
Bouten, Carlijn V. C.
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-20, 20 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-09-17
Country of Publication
Egypt
No. of Pages
20
Abstract EN
The microenvironment plays a crucial role in the behavior of stem and progenitor cells.
In the heart, cardiac progenitor cells (CPCs) reside in specific niches, characterized by key components that are altered in response to a myocardial infarction.
To date, there is a lack of knowledge on these niches and on the CPC interplay with the niche components.
Insight into these complex interactions and into the influence of microenvironmental factors on CPCs can be used to promote the regenerative potential of these cells.
In this review, we discuss cardiac resident progenitor cells and their regenerative potential and provide an overview of the interactions of CPCs with the key elements of their niche.
We focus on the interaction between CPCs and supporting cells, extracellular matrix, mechanical stimuli, and soluble factors.
Finally, we describe novel approaches to modulate the CPC niche that can represent the next step in recreating an optimal CPC microenvironment and thereby improve their regeneration capacity.
American Psychological Association (APA)
Mauretti, Arianna& Spaans, Sergio& Bax, Noortje A. M.& Sahlgren, Cecilia& Bouten, Carlijn V. C.. 2017. Cardiac Progenitor Cells and the Interplay with Their Microenvironment. Stem Cells International،Vol. 2017, no. 2017, pp.1-20.
https://search.emarefa.net/detail/BIM-1202140
Modern Language Association (MLA)
Mauretti, Arianna…[et al.]. Cardiac Progenitor Cells and the Interplay with Their Microenvironment. Stem Cells International No. 2017 (2017), pp.1-20.
https://search.emarefa.net/detail/BIM-1202140
American Medical Association (AMA)
Mauretti, Arianna& Spaans, Sergio& Bax, Noortje A. M.& Sahlgren, Cecilia& Bouten, Carlijn V. C.. Cardiac Progenitor Cells and the Interplay with Their Microenvironment. Stem Cells International. 2017. Vol. 2017, no. 2017, pp.1-20.
https://search.emarefa.net/detail/BIM-1202140
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1202140