Can Human Embryonic Stem Cell-Derived Stromal Cells Serve a Starting Material for Myoblasts?
Joint Authors
Umezawa, Akihiro
Ando, Yu
Saito, Marie
Machida, Masakazu
Yoshida-Noro, Chikako
Akutsu, Hidenori
Takahashi, Masataka
Toyoda, Masashi
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-15
Country of Publication
Egypt
No. of Pages
7
Abstract EN
A large number of myocytes are necessary to treat intractable muscular disorders such as Duchenne muscular dystrophy with cell-based therapies.
However, starting materials for cellular therapy products such as myoblasts, marrow stromal cells, menstrual blood-derived cells, and placenta-derived cells have a limited lifespan and cease to proliferate in vitro.
From the viewpoints of manufacturing and quality control, cells with a long lifespan are more suitable as a starting material.
In this study, we generated stromal cells for future myoblast therapy from a working cell bank of human embryonic stem cells (ESCs).
The ESC-derived CD105+ cells with extensive in vitro proliferation capability exhibited myogenesis and genetic stability in vitro.
These results imply that ESC-derived CD105+ cells are another cell source for myoblasts in cell-based therapy for patients with genetic muscular disorders.
Since ESCs are immortal, mesenchymal stromal cells generated from ESCs can be manufactured at a large scale in one lot for pharmaceutical purposes.
American Psychological Association (APA)
Ando, Yu& Saito, Marie& Machida, Masakazu& Yoshida-Noro, Chikako& Akutsu, Hidenori& Takahashi, Masataka…[et al.]. 2017. Can Human Embryonic Stem Cell-Derived Stromal Cells Serve a Starting Material for Myoblasts?. Stem Cells International،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1202151
Modern Language Association (MLA)
Ando, Yu…[et al.]. Can Human Embryonic Stem Cell-Derived Stromal Cells Serve a Starting Material for Myoblasts?. Stem Cells International No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1202151
American Medical Association (AMA)
Ando, Yu& Saito, Marie& Machida, Masakazu& Yoshida-Noro, Chikako& Akutsu, Hidenori& Takahashi, Masataka…[et al.]. Can Human Embryonic Stem Cell-Derived Stromal Cells Serve a Starting Material for Myoblasts?. Stem Cells International. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1202151
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1202151