Mesenchymal Stem Cells Transplantation following Partial Hepatectomy: A New Concept to Promote Liver Regeneration—Systematic Review of the Literature Focused on Experimental Studies in Rodent Models
Joint Authors
Zografos, Georgios
Papanikolaou, Ioannis G.
Katselis, Charalambos
Apostolou, Konstantinos
Feretis, Themistoklis
Lymperi, Maria
Konstadoulakis, Manousos M.
Papalois, Apostolos E.
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-22, 22 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-13
Country of Publication
Egypt
No. of Pages
22
Abstract EN
Mesenchymal stem cells (MSCs) are an attractive source for regenerative medicine because they are easily accessible through minimally invasive methods and have the potential to enhance liver regeneration (LG) and improve liver function, following partial hepatectomy (PH) and acute or chronic liver injury.
A systematic review of the literature was conducted for articles published up to September 1st, 2016, using the MEDLINE database.
The keywords that were used in various combinations were as follows: “Mesenchymal stem cells”, “transplantation”, “stem cells”, “adipose tissue derived stem cells”, “bone marrow-derived stem cells”, “partial hepatectomy”, “acute liver failure”, “chronic liver failure”, “liver fibrosis”, “liver cirrhosis”, “rats”, “mice”, and “liver regeneration”.
All introduced keywords were searched for separately in MeSH Database to control relevance and terminological accuracy and validity.
A total of 41 articles were identified for potential inclusion and reviewed in detail.
After a strict selection process, a total of 28 articles were excluded, leaving 13 articles to form the basis of this systematic review.
MSCs transplantation promoted LG and improved liver function.
Furthermore, MSCs had the ability to differentiate in hepatocyte-like cells, increase survival, and protect hepatocytes by paracrine mechanisms.
MSCs transplantation may provide beneficial effects in the process of LG after PH and acute or chronic liver injury.
They may represent a new therapeutic option to treat posthepatectomy acute liver failure.
American Psychological Association (APA)
Papanikolaou, Ioannis G.& Katselis, Charalambos& Apostolou, Konstantinos& Feretis, Themistoklis& Lymperi, Maria& Konstadoulakis, Manousos M.…[et al.]. 2017. Mesenchymal Stem Cells Transplantation following Partial Hepatectomy: A New Concept to Promote Liver Regeneration—Systematic Review of the Literature Focused on Experimental Studies in Rodent Models. Stem Cells International،Vol. 2017, no. 2017, pp.1-22.
https://search.emarefa.net/detail/BIM-1202155
Modern Language Association (MLA)
Papanikolaou, Ioannis G.…[et al.]. Mesenchymal Stem Cells Transplantation following Partial Hepatectomy: A New Concept to Promote Liver Regeneration—Systematic Review of the Literature Focused on Experimental Studies in Rodent Models. Stem Cells International No. 2017 (2017), pp.1-22.
https://search.emarefa.net/detail/BIM-1202155
American Medical Association (AMA)
Papanikolaou, Ioannis G.& Katselis, Charalambos& Apostolou, Konstantinos& Feretis, Themistoklis& Lymperi, Maria& Konstadoulakis, Manousos M.…[et al.]. Mesenchymal Stem Cells Transplantation following Partial Hepatectomy: A New Concept to Promote Liver Regeneration—Systematic Review of the Literature Focused on Experimental Studies in Rodent Models. Stem Cells International. 2017. Vol. 2017, no. 2017, pp.1-22.
https://search.emarefa.net/detail/BIM-1202155
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1202155