Epigenetic Memory of Early-Life Parental Perturbation: Dopamine Decrease and DNA Methylation Changes in Offspring

Joint Authors

Gabbianelli, Rosita
Bordoni, Laura
Nasuti, Cinzia
Di Stefano, Antonio
Marinelli, Lisa

Source

Oxidative Medicine and Cellular Longevity

Issue

Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2019-02-19

Country of Publication

Egypt

No. of Pages

11

Main Subjects

Biology

Abstract EN

Early-life exposure (from postnatal day 6 to postnatal day 21) to permethrin has been associated with long-term development of dopaminergic neurodegeneration in rats.

Here, we first investigated if the dopamine decrease observed following early postnatal exposure to permethrin, an oxidative stressor, can impair the dopamine level in the brain of their untreated offspring.

Secondly, we evaluated whether this adverse event affects the epigenome of both directly exposed rats (F0) and their untreated offspring (F1).

The results show that early-life exposure to the stressor is associated with changes in global DNA methylation and hydroxymethylation in adult age.

Furthermore, parental exposure leads to a significant reduction in dopamine level in the offspring (F1) born from parents or just mothers early-life treated (72.72% and 47.35%, respectively).

About 2/3 of pups from exposed mothers showed a significant reduction in dopamine level compared to controls.

Global DNA methylation and hydroxymethylation impairment was associated with the F1 pups that showed reduced dopamine.

This study provides pivotal evidences on intergenerational effects of postnatal exposure to permethrin emphasizing that this xenobiotic can influence the epigenetic memory of early-life parental perturbations disturbing offspring health.

American Psychological Association (APA)

Bordoni, Laura& Nasuti, Cinzia& Di Stefano, Antonio& Marinelli, Lisa& Gabbianelli, Rosita. 2019. Epigenetic Memory of Early-Life Parental Perturbation: Dopamine Decrease and DNA Methylation Changes in Offspring. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1202176

Modern Language Association (MLA)

Bordoni, Laura…[et al.]. Epigenetic Memory of Early-Life Parental Perturbation: Dopamine Decrease and DNA Methylation Changes in Offspring. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1202176

American Medical Association (AMA)

Bordoni, Laura& Nasuti, Cinzia& Di Stefano, Antonio& Marinelli, Lisa& Gabbianelli, Rosita. Epigenetic Memory of Early-Life Parental Perturbation: Dopamine Decrease and DNA Methylation Changes in Offspring. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1202176

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1202176