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Epigenetic Memory of Early-Life Parental Perturbation: Dopamine Decrease and DNA Methylation Changes in Offspring
Joint Authors
Gabbianelli, Rosita
Bordoni, Laura
Nasuti, Cinzia
Di Stefano, Antonio
Marinelli, Lisa
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-02-19
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Early-life exposure (from postnatal day 6 to postnatal day 21) to permethrin has been associated with long-term development of dopaminergic neurodegeneration in rats.
Here, we first investigated if the dopamine decrease observed following early postnatal exposure to permethrin, an oxidative stressor, can impair the dopamine level in the brain of their untreated offspring.
Secondly, we evaluated whether this adverse event affects the epigenome of both directly exposed rats (F0) and their untreated offspring (F1).
The results show that early-life exposure to the stressor is associated with changes in global DNA methylation and hydroxymethylation in adult age.
Furthermore, parental exposure leads to a significant reduction in dopamine level in the offspring (F1) born from parents or just mothers early-life treated (72.72% and 47.35%, respectively).
About 2/3 of pups from exposed mothers showed a significant reduction in dopamine level compared to controls.
Global DNA methylation and hydroxymethylation impairment was associated with the F1 pups that showed reduced dopamine.
This study provides pivotal evidences on intergenerational effects of postnatal exposure to permethrin emphasizing that this xenobiotic can influence the epigenetic memory of early-life parental perturbations disturbing offspring health.
American Psychological Association (APA)
Bordoni, Laura& Nasuti, Cinzia& Di Stefano, Antonio& Marinelli, Lisa& Gabbianelli, Rosita. 2019. Epigenetic Memory of Early-Life Parental Perturbation: Dopamine Decrease and DNA Methylation Changes in Offspring. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1202176
Modern Language Association (MLA)
Bordoni, Laura…[et al.]. Epigenetic Memory of Early-Life Parental Perturbation: Dopamine Decrease and DNA Methylation Changes in Offspring. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1202176
American Medical Association (AMA)
Bordoni, Laura& Nasuti, Cinzia& Di Stefano, Antonio& Marinelli, Lisa& Gabbianelli, Rosita. Epigenetic Memory of Early-Life Parental Perturbation: Dopamine Decrease and DNA Methylation Changes in Offspring. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1202176
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1202176