Targeting IL-17A Improves the Dysmotility of the Small Intestine and Alleviates the Injury of the Interstitial Cells of Cajal during Sepsis
Joint Authors
Jin, Xiaoming
Wang, Yufu
Li, Jing
Yan, Jinglong
Kong, Pengyu
Chen, Chao
Tang, Jing
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-08-18
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Intestinal dysmotility is a frequent complication during sepsis and plays an important role in the development of secondary infections and multiple organ failure.
However, the central mechanisms underlying this process have not been well elucidated.
Currently, effective therapies are still lacking for the treatment of sepsis-induced intestinal dysmotility.
In this study, we found that the activation of IL-17 signaling within the muscularis propria might be associated with dysmotility of the small intestine during polymicrobial sepsis.
Furthermore, we demonstrated that targeting IL-17A partially rescued the motility of the small intestine and alleviated interstitial cells of Cajal (ICC) injury during sepsis.
The blockade of IL-17A suppressed the dominant sepsis-induced infiltration of M1-polarized macrophages into the muscularis.
Additionally, impaired ICC survival may be associated with the oxidative stress injury induced by dominant infiltration of M1-polarized macrophages.
Our findings reveal the important role of the IL-17 signaling pathway in the small intestine during sepsis and provide clues for developing a novel therapeutic strategy for treating gastrointestinal dysmotility during sepsis.
American Psychological Association (APA)
Li, Jing& Kong, Pengyu& Chen, Chao& Tang, Jing& Jin, Xiaoming& Yan, Jinglong…[et al.]. 2019. Targeting IL-17A Improves the Dysmotility of the Small Intestine and Alleviates the Injury of the Interstitial Cells of Cajal during Sepsis. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1202180
Modern Language Association (MLA)
Li, Jing…[et al.]. Targeting IL-17A Improves the Dysmotility of the Small Intestine and Alleviates the Injury of the Interstitial Cells of Cajal during Sepsis. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-15.
https://search.emarefa.net/detail/BIM-1202180
American Medical Association (AMA)
Li, Jing& Kong, Pengyu& Chen, Chao& Tang, Jing& Jin, Xiaoming& Yan, Jinglong…[et al.]. Targeting IL-17A Improves the Dysmotility of the Small Intestine and Alleviates the Injury of the Interstitial Cells of Cajal during Sepsis. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1202180
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1202180