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Effect of BMP-2 Delivery Mode on Osteogenic Differentiation of Stem Cells
Joint Authors
Jung, Taekhee
Lee, John Hwan
Park, Soonjung
Kim, Yong-Jin
Seo, Joseph
Shim, Hye-Eun
Kim, Ki-Suk
Jang, Hyon-Seok
Chung, Hyung-Min
Oh, Seong-Geun
Moon, Sung-Hwan
Kang, Sun-Woong
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-19
Country of Publication
Egypt
No. of Pages
7
Abstract EN
Differentiation of stem cells is an important strategy for regeneration of defective tissue in stem cell therapy.
Bone morphogenetic protein-2 (BMP-2) is a well-known osteogenic differentiation factor that stimulates stem cell signaling pathways by activating transmembrane type I and type II receptors.
However, BMPs have a very short half-life and may rapidly lose their bioactivity.
Thus, a BMP delivery system is required to take advantage of an osteoinductive effect for osteogenic differentiation.
Previously, BMP delivery has been designed and evaluated for osteogenic differentiation, focusing on carriers and sustained release system for delivery of BMPs.
The effect of the delivery mode in cell culture plate on osteogenic differentiation potential was not evaluated.
Herein, to investigate the effect of delivery mode on osteogenic differentiation of BM-MSCs in this study, we fabricated bottom-up release and top-down release systems for culture plate delivery of BMP-2.
And also, we selected Arg-Gly-Asp- (RGD-) conjugated alginate hydrogel for BMP-2 delivery because alginate is able to release BMP-2 in a sustained manner and it is a biocompatible material.
After 7 days of culture, the bottom-up release system in culture plate significantly stimulated alkaline phosphate activity of human bone marrow-mesenchymal stem cells.
The present study highlights the potential value of the tool in stem cell therapy.
American Psychological Association (APA)
Jung, Taekhee& Lee, John Hwan& Park, Soonjung& Kim, Yong-Jin& Seo, Joseph& Shim, Hye-Eun…[et al.]. 2017. Effect of BMP-2 Delivery Mode on Osteogenic Differentiation of Stem Cells. Stem Cells International،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1202187
Modern Language Association (MLA)
Jung, Taekhee…[et al.]. Effect of BMP-2 Delivery Mode on Osteogenic Differentiation of Stem Cells. Stem Cells International No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1202187
American Medical Association (AMA)
Jung, Taekhee& Lee, John Hwan& Park, Soonjung& Kim, Yong-Jin& Seo, Joseph& Shim, Hye-Eun…[et al.]. Effect of BMP-2 Delivery Mode on Osteogenic Differentiation of Stem Cells. Stem Cells International. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1202187
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1202187