![](/images/graphics-bg.png)
Progenitor Cells for Arterial Repair: Incremental Advancements towards Therapeutic Reality
Joint Authors
Simard, Trevor
Jung, Richard G.
Motazedian, Pouya
Di Santo, Pietro
Ramirez, F. Daniel
Russo, Juan J.
Labinaz, Alisha
Yousef, Altayyeb
Anantharam, Brijesh
Pourdjabbar, Ali
Hibbert, Benjamin
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-23
Country of Publication
Egypt
No. of Pages
14
Abstract EN
Coronary revascularization remains the standard treatment for obstructive coronary artery disease and can be accomplished by either percutaneous coronary intervention (PCI) or coronary artery bypass graft surgery.
Considerable advances have rendered PCI the most common form of revascularization and improved clinical outcomes.
However, numerous challenges to modern PCI remain, namely, in-stent restenosis and stent thrombosis, underscoring the importance of understanding the vessel wall response to injury to identify targets for intervention.
Among recent promising discoveries, endothelial progenitor cells (EPCs) have garnered considerable interest given an increasing appreciation of their role in vascular homeostasis and their ability to promote vascular repair after stent placement.
Circulating EPC numbers have been inversely correlated with cardiovascular risk, while administration of EPCs in humans has demonstrated improved clinical outcomes.
Despite these encouraging results, however, advancing EPCs as a therapeutic modality has been hampered by a fundamental roadblock: what constitutes an EPC? We review current definitions and sources of EPCs as well as the proposed mechanisms of EPC-mediated vascular repair.
Additionally, we discuss the current state of EPCs as therapeutic agents, focusing on endogenous augmentation and transplantation.
American Psychological Association (APA)
Simard, Trevor& Jung, Richard G.& Motazedian, Pouya& Di Santo, Pietro& Ramirez, F. Daniel& Russo, Juan J.…[et al.]. 2017. Progenitor Cells for Arterial Repair: Incremental Advancements towards Therapeutic Reality. Stem Cells International،Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1202231
Modern Language Association (MLA)
Simard, Trevor…[et al.]. Progenitor Cells for Arterial Repair: Incremental Advancements towards Therapeutic Reality. Stem Cells International No. 2017 (2017), pp.1-14.
https://search.emarefa.net/detail/BIM-1202231
American Medical Association (AMA)
Simard, Trevor& Jung, Richard G.& Motazedian, Pouya& Di Santo, Pietro& Ramirez, F. Daniel& Russo, Juan J.…[et al.]. Progenitor Cells for Arterial Repair: Incremental Advancements towards Therapeutic Reality. Stem Cells International. 2017. Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1202231
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1202231