Intestinal Stem Cell Niche Insights Gathered from Both In Vivo and Novel In Vitro Models
Joint Authors
Gjorevski, Nikolce
Ordóñez-Morán, Paloma
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-09-07
Country of Publication
Egypt
No. of Pages
10
Abstract EN
Intestinal stem cells are located at the base of the crypts and are surrounded by a complex structure called niche.
This environment is composed mainly of epithelial cells and stroma which provides signals that govern cell maintenance, proliferation, and differentiation.
Understanding how the niche regulates stem cell fate by controlling developmental signaling pathways will help us to define how stem cells choose between self-renewal and differentiation and how they maintain their undifferentiated state.
Tractable in vitro assay systems, which reflect the complexity of the in vivo situation but provide higher level of control, would likely be crucial in identifying new players and mechanisms controlling stem cell function.
Knowledge of the intestinal stem cell niche gathered from both in vivo and novel in vitro models may help us improve therapies for tumorigenesis and intestinal damage and make autologous intestinal transplants a feasible clinical practice.
American Psychological Association (APA)
Gjorevski, Nikolce& Ordóñez-Morán, Paloma. 2017. Intestinal Stem Cell Niche Insights Gathered from Both In Vivo and Novel In Vitro Models. Stem Cells International،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1202260
Modern Language Association (MLA)
Gjorevski, Nikolce& Ordóñez-Morán, Paloma. Intestinal Stem Cell Niche Insights Gathered from Both In Vivo and Novel In Vitro Models. Stem Cells International No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1202260
American Medical Association (AMA)
Gjorevski, Nikolce& Ordóñez-Morán, Paloma. Intestinal Stem Cell Niche Insights Gathered from Both In Vivo and Novel In Vitro Models. Stem Cells International. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1202260
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1202260