A Novel Thiazolyl Schiff Base: Antibacterial and Antifungal Effects and In Vitro Oxidative Stress Modulation on Human Endothelial Cells
Joint Authors
Bâldea, Ioana
Decea, Nicoleta
Login, Cristian Cezar
Tiperciuc, Brînduşa
Benedec, Daniela
Vodnar, Dan Cristian
Suciu, Şoimiţa
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-10-10
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Schiff bases (SBs) are chemical compounds displaying a significant pharmacological potential.
They are able to modulate the activity of many enzymes involved in metabolism and are found among antibacterial, antifungal, anti-inflammatory, antioxidant, and antiproliferative drugs.
A new thiazolyl-triazole SB was obtained and characterized by elemental and spectral analysis.
The antibacterial and antifungal ability of the SB was evaluated against Gram-positive and Gram-negative bacteria and against three Candida strains.
SB showed good antibacterial activity against L.
monocytogenes and P.
aeruginosa; it was two times more active than ciprofloxacin.
Anti-Candida activity was twofold higher compared with that of fluconazole.
The effect of the SB on cell viability was evaluated by colorimetric measurement on cell cultures exposed to various SB concentrations.
The ability of the SB to modulate oxidative stress was assessed by measuring MDA, TNF-α, SOD1, COX2, and NOS2 levels in vitro, using human endothelial cell cultures exposed to a glucose-enriched medium.
SB did not change the morphology of the cells.
Experimental findings indicate that the newly synthetized Schiff base has antibacterial activity, especially on the Gram-negative P.
aeruginosa, and antifungal activity.
SB also showed antioxidant and anti-inflammatory activities.
American Psychological Association (APA)
Login, Cristian Cezar& Bâldea, Ioana& Tiperciuc, Brînduşa& Benedec, Daniela& Vodnar, Dan Cristian& Decea, Nicoleta…[et al.]. 2019. A Novel Thiazolyl Schiff Base: Antibacterial and Antifungal Effects and In Vitro Oxidative Stress Modulation on Human Endothelial Cells. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1202262
Modern Language Association (MLA)
Login, Cristian Cezar…[et al.]. A Novel Thiazolyl Schiff Base: Antibacterial and Antifungal Effects and In Vitro Oxidative Stress Modulation on Human Endothelial Cells. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1202262
American Medical Association (AMA)
Login, Cristian Cezar& Bâldea, Ioana& Tiperciuc, Brînduşa& Benedec, Daniela& Vodnar, Dan Cristian& Decea, Nicoleta…[et al.]. A Novel Thiazolyl Schiff Base: Antibacterial and Antifungal Effects and In Vitro Oxidative Stress Modulation on Human Endothelial Cells. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1202262
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1202262