![](/images/graphics-bg.png)
Gut Mesenchymal Stromal Cells in Immunity
Joint Authors
Signore, Michele
Biancone, Livia
Messina, Valeria
Buccione, Carla
Marotta, Giulia
Ziccheddu, Giovanna
Mattia, Gianfranco
Puglisi, Rossella
Sacchetti, Benedetto
Valtieri, Mauro
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-28
Country of Publication
Egypt
No. of Pages
6
Abstract EN
Mesenchymal stromal cells (MSCs), first found in bone marrow (BM), are the structural architects of all organs, participating in most biological functions.
MSCs possess tissue-specific signatures that allow their discrimination according to their origin and location.
Among their multiple functions, MSCs closely interact with immune cells, orchestrating their activity to maintain overall homeostasis.
The phenotype of tissue MSCs residing in the bowel overlaps with myofibroblasts, lining the bottom walls of intestinal crypts (pericryptal) or interspersed within intestinal submucosa (intercryptal).
In Crohn’s disease, intestinal MSCs are tightly stacked in a chronic inflammatory milieu, which causes their enforced expression of Class II major histocompatibility complex (MHC).
The absence of Class II MHC is a hallmark for immune-modulator and tolerogenic properties of normal MSCs and, vice versa, the expression of HLA-DR is peculiar to antigen presenting cells, that is, immune-activator cells.
Interferon gamma (IFNγ) is responsible for induction of Class II MHC expression on intestinal MSCs.
The reversal of myofibroblasts/MSCs from an immune-modulator to an activator phenotype in Crohn’s disease results in the formation of a fibrotic tube subverting the intestinal structure.
Epithelial metaplastic areas in this context can progress to dysplasia and cancer.
American Psychological Association (APA)
Messina, Valeria& Buccione, Carla& Marotta, Giulia& Ziccheddu, Giovanna& Signore, Michele& Mattia, Gianfranco…[et al.]. 2017. Gut Mesenchymal Stromal Cells in Immunity. Stem Cells International،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1202268
Modern Language Association (MLA)
Messina, Valeria…[et al.]. Gut Mesenchymal Stromal Cells in Immunity. Stem Cells International No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1202268
American Medical Association (AMA)
Messina, Valeria& Buccione, Carla& Marotta, Giulia& Ziccheddu, Giovanna& Signore, Michele& Mattia, Gianfranco…[et al.]. Gut Mesenchymal Stromal Cells in Immunity. Stem Cells International. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1202268
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1202268