The DEAD-Box RNA Helicase DDX3 Interacts with m6A RNA Demethylase ALKBH5
Joint Authors
Hu, Shanshan
Shan, Ge
Shah, Abdullah
Rashid, Farooq
Awan, Hassaan Mehboob
Wang, Xiaolin
Chen, Liang
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-23
Country of Publication
Egypt
No. of Pages
11
Abstract EN
DDX3 is a member of the family of DEAD-box RNA helicases.
DDX3 is a multifaceted helicase and plays essential roles in key biological processes such as cell cycle, stress response, apoptosis, and RNA metabolism.
In this study, we found that DDX3 interacted with ALKBH5, an m6A RNA demethylase.
The ATP domain of DDX3 and DSBH domain of ALKBH5 were indispensable to their interaction with each other.
Furthermore, DDX3 could modulate the demethylation of mRNAs.
We also showed that DDX3 regulated the methylation status of microRNAs and there was an interaction between DDX3 and AGO2.
The dynamics of m6A RNA modification is still a field demanding further investigation, and here, we add a link by showing that RNA demethylation can be regulated by proteins such as DDX3.
American Psychological Association (APA)
Shah, Abdullah& Rashid, Farooq& Awan, Hassaan Mehboob& Hu, Shanshan& Wang, Xiaolin& Chen, Liang…[et al.]. 2017. The DEAD-Box RNA Helicase DDX3 Interacts with m6A RNA Demethylase ALKBH5. Stem Cells International،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1202274
Modern Language Association (MLA)
Shah, Abdullah…[et al.]. The DEAD-Box RNA Helicase DDX3 Interacts with m6A RNA Demethylase ALKBH5. Stem Cells International No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1202274
American Medical Association (AMA)
Shah, Abdullah& Rashid, Farooq& Awan, Hassaan Mehboob& Hu, Shanshan& Wang, Xiaolin& Chen, Liang…[et al.]. The DEAD-Box RNA Helicase DDX3 Interacts with m6A RNA Demethylase ALKBH5. Stem Cells International. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1202274
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1202274