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Endothelial Dysfunction in Cystic Fibrosis: Role of Oxidative Stress
Joint Authors
Davison, Gareth W.
Tucker, Matthew A.
Fox, Brandon M.
Seigler, Nichole
Rodriguez-Miguelez, Paula
Looney, Jacob
Thomas, Jeffrey
McKie, Kathleen T.
Forseen, Caralee
Harris, Ryan A.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-06-19
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Oxidative stress and vascular endothelial dysfunction are established characteristics of cystic fibrosis (CF).
Oxidative stress may contribute to vascular dysfunction via inhibition of nitric oxide (NO) bioavailability.
Purpose.
To determine if ingestion of a single antioxidant cocktail (AOC) improves vascular endothelial function in patients with CF.
Methods.
In 18 patients with CF (age 8-39 y), brachial artery flow-mediated dilation (FMD) was assessed using a Doppler ultrasound prior to and two hours following either an AOC (n=18; 1,000 mg vitamin C, 600 IU vitamin E, and 600 mg α-lipoic acid) or a placebo (n=9).
In a subgroup of patients (n=9), changes in serum concentrations of α-tocopherol and lipid hydroperoxide (LOOH) were assessed following AOC and placebo.
Results.
A significant (p=0.032) increase in FMD was observed following AOC (Δ1.9±3.3%), compared to no change following placebo (Δ−0.8±1.9%).
Moreover, compared with placebo, AOC prevented the decrease in α-tocopherol (Δ0.48±2.91 vs.
−1.98±2.32 μM, p=0.024) and tended to decrease LOOH (Δ−0.2±0.1 vs.
0.1±0.1 μM, p=0.063).
Conclusions.
These data demonstrate that ingestion of an antioxidant cocktail can improve vascular endothelial function and improve oxidative stress in patients with CF, providing evidence that oxidative stress is a key contributor to vascular endothelial dysfunction in CF.
American Psychological Association (APA)
Tucker, Matthew A.& Fox, Brandon M.& Seigler, Nichole& Rodriguez-Miguelez, Paula& Looney, Jacob& Thomas, Jeffrey…[et al.]. 2019. Endothelial Dysfunction in Cystic Fibrosis: Role of Oxidative Stress. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1202275
Modern Language Association (MLA)
Tucker, Matthew A.…[et al.]. Endothelial Dysfunction in Cystic Fibrosis: Role of Oxidative Stress. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1202275
American Medical Association (AMA)
Tucker, Matthew A.& Fox, Brandon M.& Seigler, Nichole& Rodriguez-Miguelez, Paula& Looney, Jacob& Thomas, Jeffrey…[et al.]. Endothelial Dysfunction in Cystic Fibrosis: Role of Oxidative Stress. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1202275
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1202275